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Dysregulation of HAO2 is a very early event in the development of hepatocellular carcinoma (HCC).
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed predominantly in liver and kidney and has the highest activity toward the substrate 2-hydroxypalmitate. Two alternatively spliced variants encoding the same isoform have been described.
(S)-2-hydroxy-acid oxidase, peroxisomal
, cell growth-inhibiting gene 16 protein
, glycolate oxidase
, hydroxyacid oxidase 2
, long chain alpha-hydroxy acid oxidase
, long-chain L-2-hydroxy acid oxidase
, hydroxyacid oxidase (glycolate oxidase) 3
, hydroxyacid oxidase 2, kidney
, medium chain alpha-hydroxy acid oxidase
, medium-chain 2-hydroxy acid oxidase HAOX3
, medium-chain L-2-hydroxy acid oxidase
, hydroxyacid oxidase 3 (medium-chain)
, (S)-hydroxy-acid oxidase, peroxisomal
, hydroxyacid oxidase 2 (long chain)
, hydroxyacid oxidase 2 (long chain) S homeolog