MCM8 抗体
(Minichromosome Maintenance Deficient 8 (MCM8))
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Latest Publications for our MCM8 抗体
: "RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination." in: Molecular cell, Vol. 66, Issue 5, pp. 622-634.e8, (2017) (PubMed).
: "The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination." in: Molecular and cellular biology, Vol. 33, Issue 8, pp. 1632-44, (2013) (PubMed).
: "Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues." in: Human pathology, Vol. 40, Issue 1, pp. 41-9, (2008) (PubMed).
: "The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination." in: Molecular and cellular biology, Vol. 33, Issue 8, pp. 1632-44, (2013) (PubMed).
: "Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues." in: Human pathology, Vol. 40, Issue 1, pp. 41-9, (2008) (PubMed).
Aliases for MCM8 抗体
minichromosome maintenance 8 homologous recombination repair factor (MCM8) 抗体minichromosome maintenance 8 homologous recombination repair factor (Mcm8) 抗体
minichromosome maintenance 8 homologous recombination repair factor L homeolog (mcm8.L) 抗体
5730432L01Rik 抗体
C20orf154 抗体
dJ967N21.5 抗体
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