MDM4-binding Protein 抗体
(Mdm4-binding Protein (MDM4))
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| MDM4-binding Protein 抗体 (AA 1-490) | 人 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 | 人 | 小鼠 Monoclonal |
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| MDM4-binding Protein 抗体 | 人 | 小鼠 Monoclonal |
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| Recombinant MDM4-binding Protein 抗体 (AA 125-175) | 人 | 兔 Monoclonal |
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| Recombinant MDM4-binding Protein 抗体 (AA 125-175) | 人 | 兔 Monoclonal |
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| MDM4-binding Protein 抗体 | 人 | 小鼠 Monoclonal |
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| MDM4-binding Protein 抗体 (AA 1-490) | 人 | 小鼠 Polyclonal |
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| MDM4-binding Protein 抗体 (AA 130-179) | 人, Cow, Pig, 兔 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (pSer367) | 人 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (AA 301-400) | 人 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (AA 128-157) | 人 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (AA 101-150) | 人, Cow, Pig, 兔 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (Internal Region) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (AA 208-306) | 人 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (Ser885) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (N-Term) | 人, Cow, 犬 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (Internal Region) | 人, 小鼠, 大鼠 | 小鼠 Monoclonal |
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| MDM4-binding Protein 抗体 (AA 381-490) | 人 | 小鼠 Polyclonal |
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| MDM4-binding Protein 抗体 (N-Term) | 人, 小鼠 | 兔 Polyclonal |
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| MDM4-binding Protein 抗体 (N-Term) | 人, Cow, Pig, 兔, 犬, 马 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- IP (Immunoprecipitation: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-490
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- ELISA (ELISA: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
2 references - 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 2D10F4
- 标记
- unconjugated
- 抗体亚型
- IgG1
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 2D11
- 标记
- unconjugated
- 抗体亚型
- IgG2a
Primary Antibody
- WB (Western Blotting: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- BL-3-2F2
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG
- 抗原表位
- AA 125-175
Primary Antibody
- WB (Western Blotting: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Monoclonal
- 克隆
- BL-3-2F2
- 标记
- unconjugated
- 蛋白类型
- Recombinant Antibody
- 抗体亚型
- IgG
- 抗原表位
- AA 125-175
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 3A6
- 标记
- unconjugated
- 抗体亚型
- IgG2b
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1-490
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- IHC (fp) (Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections): 有验证图片)
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人, Cow, Pig, 兔
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 130-179
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- pSer367
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IF (cc) (Immunofluorescence (Cultured Cells): 所列应用)
- IF (p) (Immunofluorescence (Paraffin-embedded Sections): 所列应用)
- IHC (fro) (Immunohistochemistry (Frozen Sections): 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 301-400
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB33903
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 128-157
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Internal Region
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 208-306
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Ser885
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, Cow, 犬
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- AFfirm8320
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- Internal Region
Primary Antibody
- WB (Western Blotting: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 381-490
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, Cow, Pig, 兔, 犬, 马
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- N-Term
Latest Publications for our MDM4-binding Protein 抗体
: "MDM4 expression in fibrolamellar hepatocellular carcinoma." in: Oncology reports, (2019) (PubMed).
: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." in: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).
: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." in: Oncogene, (2015) (PubMed).
: "Protumorigenic role of Timeless in hepatocellular carcinoma." in: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).
: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).
: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).
: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).
: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).
: "TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases." in: British journal of haematology, Vol. 158, Issue 6, pp. 763-71, (2012) (PubMed).
: "MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame." in: PLoS ONE, Vol. 7, Issue 8, pp. e42034, (2012) (PubMed).
: "MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability." in: Molecular cancer, Vol. 16, Issue 1, pp. 55, (2017) (PubMed).
: "MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response." in: Oncogene, (2015) (PubMed).
: "Protumorigenic role of Timeless in hepatocellular carcinoma." in: International journal of oncology, Vol. 46, Issue 2, pp. 597-606, (2014) (PubMed).
: "Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma." in: Neoplasia (New York, N.Y.), Vol. 15, Issue 9, pp. 1049-63, (2013) (PubMed).
: "MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress." in: Molecular and cellular biology, Vol. 32, Issue 7, pp. 1214-25, (2012) (PubMed).
: "Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein." in: The Journal of biological chemistry, Vol. 287, Issue 25, pp. 20898-903, (2012) (PubMed).
: "p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors." in: PLoS ONE, Vol. 7, Issue 5, pp. e37776, (2012) (PubMed).
: "TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases." in: British journal of haematology, Vol. 158, Issue 6, pp. 763-71, (2012) (PubMed).
: "MicroRNA-34a modulates MDM4 expression via a target site in the open reading frame." in: PLoS ONE, Vol. 7, Issue 8, pp. e42034, (2012) (PubMed).
Aliases for MDM4-binding Protein 抗体
MDM4, p53 regulator S homeolog (mdm4.S) 抗体MDM4, p53 regulator (MDM4) 抗体
MDM4, p53 regulator (Mdm4) 抗体
MDM4, p53 regulator (mdm4) 抗体
transformed mouse 3T3 cell double minute 4 (Mdm4) 抗体
4933417N07Rik 抗体
AA414968 抗体
AL023055 抗体
AU018793 抗体
AU021806 抗体
C85810 抗体
HDMX 抗体
mdmx 抗体
MDMX 抗体
Mdmx 抗体
MRP1 抗体
wu:fa09h09 抗体
wu:fi33d10 抗体
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