MCM6 抗体
(Minichromosome Maintenance Complex Component 6 (MCM6))
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012].
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Latest Publications for our MCM6 抗体
: "Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate." in: Oncotarget, Vol. 5, Issue 5, pp. 1326-37, (2014) (PubMed).: "A five-gene and corresponding protein signature for stage-I lung adenocarcinoma prognosis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 6, pp. 1490-501, (2011) (PubMed).
: "Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France." in: Diagnostic microbiology and infectious disease, Vol. 55, Issue 1, pp. 55-8, (2006) (PubMed).
: "Stepwise regulated chromatin assembly of MCM2-7 proteins." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8426-31, (2000) (PubMed).
: "Distinct phosphoisoforms of the Xenopus Mcm4 protein regulate the function of the Mcm complex." in: Molecular and cellular biology, Vol. 20, Issue 10, pp. 3667-76, (2000) (PubMed).
: "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8003-15, (2000) (PubMed).
: "A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location." in: Genomics, Vol. 37, Issue 1, pp. 131-4, (1997) (PubMed).
Aliases for MCM6 抗体
Minichromosome maintenance 6 (Mcm6) 抗体DNA replication licensing factor MCM6 (TP02_0113) 抗体
DNA replication licensing factor MCM6 (PVX_114735) 抗体
DNA replication licensing factor MCM6 (CMU_027970) 抗体
minichromosome maintenance complex component 6 (MCM6) 抗体
minichromosome maintenance complex component 6 (Mcm6) 抗体
minichromosome maintenance complex component 6 L homeolog (mcm6.L) 抗体
DNA replication licensing factor mcm-6 (mcm-6) 抗体
ASP-l1 抗体
CG4039 抗体
D1Wsu22e 抗体
Dmel\\CG4039 抗体
DmeMCM6 抗体
DmMCM6 抗体
fs(1)K1214 抗体
MCG40308 抗体
MCM6 抗体
McM6 抗体
mcm6 抗体
Mcmd6 抗体
Mis5 抗体
mis5 抗体
mmcm6 抗体
P105MCM 抗体
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