MCM6 抗体 (AA 331-380)
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北京 101111
Quick Overview for MCM6 抗体 (AA 331-380) (ABIN6579413)
抗原
See all MCM6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 331-380
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原理
- MCM6 Antibody
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特异性
- MCM6 Polyclonal Antibody detects endogenous levels of MCM6 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380
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亚型
- IgG
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应用备注
- WB 1:500-2000,IHC 1:50-300
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
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别名
- MCM6
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背景
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Synonyms: MCM6, DNA replication licensing factor MCM6, p105MCM
Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i
Gene Name: MCM6
Protein Name: DNA replication licensing factor MCM6
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分子量
- 92 kDa
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基因ID
- 4175
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UniProt
- Q14566
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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