(Mitogen-Activated Protein Kinase Kinase Kinase 1 (MAP3K1))
The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012].
Craig, Parker, Austin, Barnett, Camenisch: "Involvement of the MEKK1 signaling pathway in the regulation of epicardial cell behavior by hyaluronan." in: Cellular signalling, Vol. 22, Issue 6, pp. 968-76, (2010) (PubMed).
Mokhtari, Myers, Welsh: "MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells." in: Diabetes, Vol. 57, Issue 7, pp. 1896-904, (2008) (PubMed).