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抗Rat (Rattus) MAP2K5 抗体:
抗Human MAP2K5 抗体:
抗Mouse (Murine) MAP2K5 抗体:
Dog (Canine) Monoclonal MAP2K5 Primary Antibody for IF, WB - ABIN968273
English, Vanderbilt, Xu, Marcus, Cobb: Isolation of MEK5 and differential expression of alternatively spliced forms. in The Journal of biological chemistry 1996
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Human Monoclonal MAP2K5 Primary Antibody for IF, WB - ABIN968272
Zhou, Bao, Dixon: Components of a new human protein kinase signal transduction pathway. in The Journal of biological chemistry 1995
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Human Polyclonal MAP2K5 Primary Antibody for IF (p), IHC (p) - ABIN754183
Chen, Hou, Ye, Chen, Cui, Tian, Li, Liu: MicroRNA-143 regulates adipogenesis by modulating the MAP2K5-ERK5 signaling. in Scientific reports 2014
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Chicken Polyclonal MAP2K5 Primary Antibody for WB - ABIN2475554
Cameron, Abe, Malik, Che, Yang: Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation. in The Journal of biological chemistry 2004
For gain and loss of function studies, constitutively active MEK5 (CA-MEK5) and ERK5 (显示 MAPK7 抗体) shRNA lentiviruses were used to activate or knock down extracellular signal-regulated kinase 5 (ERK5 (显示 MAPK7 抗体)). Our results confirmed that low concentrations of H2O2 promoted HUVECs angiogenesis in vitro, and ERK5 (显示 MAPK7 抗体) is an essential mediator of this process. Therefore, ERK5 (显示 MAPK7 抗体) may be a potential therapeutic target for promoting angiogenesis
results confirmed the association of BTBD9 (显示 BTBD9 抗体) and MAP2K5/SKOR1 (显示 SKOR1 抗体) with primary Restless Legs Syndrome in Chinese population
Results revealed the expression of MEK5 was higher in tumor tissues and provide evidence that MEK5 plays an important role in colorectal cancer progression.
Insights into a molecular mechanism by which MEK5 transcriptionally upregulated by Stat3 (显示 STAT3 抗体) augments breast cancer cell EMT (显示 ITK 抗体), which subsequently enhances cancer cell invasion and metastasis. This finding may suggest that Stat3 (显示 STAT3 抗体) and MEK5/Erk5 (显示 MAPK7 抗体) pathways could be an effective therapeutic target for inhibition of breast cancer invasion and metastasis.
Our findings confirm an association between the BTBD9 (显示 BTBD9 抗体), MEIS1 (显示 MEIS1 抗体), and MAP2K5/SKOR1 (显示 SKOR1 抗体) SNPs and periodic limb movements of sleep in an elderly cohort.
Specifically, CKS1B (显示 CKS1B 抗体) and MAP2K5 significantly inhibited hepatitis C viral RNA replication. PACSIN1 (显示 PACSIN1 抗体), by contrast, inhibited hepatitis C virus infection by decreasing the level of viral protein p7.
High MEK5 expression is associated with colorectal cancer.
SEC16B, MC4R, MAP2K5 and KCTD15 (rs17782313, rs543874, rs2241423 and rs11084753) polymorphisms are associated with the risk for children obesity in China.
Periodic leg movements during sleep are associated with polymorphisms in BTBD9 (显示 BTBD9 抗体), TOX3 (显示 TOX3 抗体)/BC034767, MEIS1 (显示 MEIS1 抗体), MAP2K5/SKOR1 (显示 SKOR1 抗体), and PTPRD (显示 PTPRD 抗体)
Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2 (显示 MAP3K2 抗体)/3-MEK5-ERK5 (显示 MAPK7 抗体) signaling.
These results suggest that YAP (显示 YAP1 抗体) promotes muscle differentiation by activating the Abl (显示 ABL1 抗体)/Src (显示 SRC 抗体)/MEKK3 (显示 MAP3K3 抗体)/MEK5/ERK5 (显示 MAPK7 抗体) kinase cascade.
MEK5 overexpression inhibits differentiation of osteoblasts.
the MEK5-ERK5 (显示 MAPK7 抗体) MAP kinase (显示 MAPK1 抗体) signaling pathway has a critical role in BAFF (显示 TNFSF13B 抗体)-induced mature B cell survival and homeostatic maintenance of B2 cell numbers
The MEK5/ERK5 (显示 MAPK7 抗体) pathway also mediates FSS-induced Runx-2 (显示 RUNX2 抗体) expression in osteoblast differentiation.
finding suggested that REST promoted primordial germ cells survival via regulation of the Mek5 expression
PB1 (显示 GPR97 抗体) domain mediates the association of MEKK2 (显示 MAP3K2 抗体) and MEKK3 (显示 MAP3K3 抗体) with MEK5 and that the respective PB1 (显示 GPR97 抗体) domains of these kinases are critical for regulation of the ERK5 (显示 MAPK7 抗体) pathway.
MEK5 is an activator of ERK5 (显示 MAPK7 抗体) and an essential regulator of cell survival that is required for normal embryonic development
the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 (显示 MAPK7 抗体) signaling pathway
MEK5 and big MAP kinase 1 (BMK1 (显示 MAPK7 抗体)) function downstream of MEKK3 (显示 MAP3K3 抗体) in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 (显示 PPP3R1 抗体)
A noncanonical function of Map2k5 domain is decribed for coordinated erk5 (显示 MAPK7 抗体) kinase and map2k7 (显示 MAP2K7 抗体) signaling.
results indicated that AIK1-MKK5-MPK6 (显示 MAPK6 抗体) functions in ABA responses and requires ABA-responsive gene expression to regulate ABA-inhibited root growth and cell division. The ABA signaling pathway regulates this MAPK (显示 MAPK1 抗体) cascade.
AIK1-MKK5-MPK6 (显示 MAPK6 抗体) cascade functions in the abscisic acid regulation of primary root growth and stomatal response.
MKK4 (显示 MAP2K4 抗体), MKK5, MKK7 (显示 MAP2K7 抗体), and MKK9, are responsible for the activation of MPK3 (显示 MAPK3 抗体) and MPK6 (显示 MAPK6 抗体) by melatonin, indicating that melatonin-mediated innate immunity is triggered by MAPK (显示 MAPK1 抗体) signaling through MKK4 (显示 MAP2K4 抗体)/5/7/9-MPK3 (显示 MAPK3 抗体)/6 cascades.
Overexpression of MKK5 in wild-type plants enhanced their tolerance to salt treatments. Another kinase, MPK6 (显示 MAPK6 抗体), was also involved in the MKK5-mediated iron superoxide dismutase (FSD) signalling pathway in salt stress.
our data indicate that EDR1 (显示 PHC1 抗体) physically associates with MKK4 (显示 MAP2K4 抗体)/MKK5 and negatively regulates the MAPK (显示 MAPK1 抗体) cascade to fine-tune plant innate immunity.
Data indicate that in the MKK5-RNAi (RNA interference) lines, the induction of CSD1 and CSD2 (显示 TGFB1 抗体) as well as the activation of MKK5 activity were completely arrested.
Results suggest that the YDA-MKK4 (显示 MAP2K4 抗体)/MKK5-MPK3 (显示 MAPK3 抗体)/MPK6 (显示 MAPK6 抗体) cascade functions downstream of the ER receptor in regulating localized cell proliferation, which further shapes the morphology of plant organs.
MKK5 functions both in ozone-induced activation of MPK3 (显示 MAPK3 抗体) and MPK6 (显示 MAPK6 抗体) and in integrating reactive oxygen species homeostasis during ozone stress.
MKK5 is a key regulator of stomatal development and patterning.
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
MAP kinase kinase 5
, MAPK/ERK kinase 5
, MAPKK 5
, MEK 5
, dual specificity mitogen-activated protein kinase kinase 5
, mitogen-activated protein kinase kinase 5
, MAP kinase kinase MEK5b
, MAPK/ERK kinese 5
, mitogen activated protein kinase kinase 5