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ninein is localized at the centrosome in undifferentiated neural precursors; but ninein was barely detected in migrating neurons, such as those in the intermediate layer of the cerebral cortex and the internal granular layer of the cerebellar cortex
Our analyses suggest a relationship with prenatal neurogenesis and identify the human data point as an outlier, possibly explained by postnatal changes in development on the human lineage.
Ninein influences the rate of axonal growth and branching by affecting microtubule stability and dynamics.
JAK2 Tyrosine Kinase phosphorylates centrosomal protein ninein, which negatively regulates it
A Ninein (NIN) missense mutation identified in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype.
The role of hNinein isoform 6 expression in cell differentiation was assessed in BrdU-treated IMR-32 cells
The prevalence of hNinein autoreactivity and its specificity in 22 rheumatoid arthritis and 32 systemic lupus erythematosus autoimmune disease sera.
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein.
Two single nucleotide polymorphisms in the APC and NIN loci were significantly associated with pancreatic cancer risk
Ninein is essential for the reformation of specific aspects of the interphase centrosome architecture following mitosis as well as being required for the centrosome to function as a MTOC.
ninein protein has two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle
Elevated ninein causes mislocalization of gamma-tubulin, recruiting it to ectopic (noncentrosomal) ninein-containing sites which are not active in nucleating microtubules, suggesting a regulatory role for ninein in microtubule nucleation.
We propose that ninein constitutes a molecular link between microtubule-nucleation and -anchoring activities at the centrosome.
our findings place SUMOylation target on the centrosome structure protein, hNinein, which results in the switch localization from centrosome to nucleus
Overexpression of ninein and the ninein-like protein NIP induces fragmentation of the Golgi and causes lysosomes to disperse toward the cell periphery.
analysis of human ninein isoforms that are regulated by centrosomal targeting signals and bind to gamma-tubulin
hNinein regulates the dynamic movement of Astrin throughout the cell cycle and this interaction, in turn, is required for maintenance of centrosome/spindle pole integrity.
Data show that ninein is highly dynamic and that, in epithelial cells, it is present not only at the centrosome but also in the cytoplasm as distinct speckles.
This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.
ninein (GSK3B interacting protein)
, glycogen synthase kinase 3 beta-interacting protein
, ninein centrosomal protein