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Whereas CENP-C recruits a single MIS12:NDC80 (显示 NDC80 蛋白) complex, the authors show here that CENP-T (显示 CENPT 蛋白) binds one MIS12:NDC80 (显示 NDC80 蛋白) and two NDC80 (显示 NDC80 蛋白) complexes upon phosphorylation by the mitotic CDK1 (显示 CDK1 蛋白):Cyclin B complex at three distinct CENP-T (显示 CENPT 蛋白) sites.
Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1 (显示 CASC5 蛋白)/MIS12/NDC80 (显示 NDC80 蛋白) at human kinetochores.
RWD-containing proteins interact with the Mis12 complex to shape KMN network topology, as revealed by structural analysis
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.
These findings support a novel role for Hsp90 (显示 HSP90 蛋白)-Sgt1 (显示 SUGT1 蛋白) chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly.
hMIS12 has a role in mitosis and localizes at kinetochores
These results indicate that a four-subunit Mis12 complex plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly.
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis (By similarity).
, MIS12, MIND kinetochore complex component, homolog
, homolog of yeast Mis12
, protein MIS12 homolog
, MIS12, MIND kinetochore complex component, homolog (S. pombe)
, liver regeneration-related protein LRRG112
, kinetochore protein Mis12