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抗Human Prohibitin 2 抗体:
抗Mouse (Murine) Prohibitin 2 抗体:
抗Rat (Rattus) Prohibitin 2 抗体:
Human Polyclonal Prohibitin 2 Primary Antibody for ICC, IF - ABIN151315
He, Feng, Mukherjee, Lonard, DeMayo, Katzenellenbogen, Lydon, OMalley: A repressive role for prohibitin in estrogen signaling. in Molecular endocrinology (Baltimore, Md.) 2008
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Human Polyclonal Prohibitin 2 Primary Antibody for IP, WB - ABIN151317
Heidler, Al-Furoukh, Kukat, Salwig, Ingelmann, Seibel, Krüger, Holtz, Wittig, Braun, Szibor: Nitric oxide-associated protein 1 (NOA1) is necessary for oxygen-dependent regulation of mitochondrial respiratory complexes. in The Journal of biological chemistry 2011
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Taken together, the results indicate that PHB2 plays a central role in p21 (显示 CDKN1A 抗体) upregulation following GGCT (显示 GGCT 抗体) knockdown and as such may promote deregulated proliferation of cancer cells by suppressing p21 (显示 CDKN1A 抗体).
analysis of LGALS3, PHB2, MUC1, and GK2 expression with CA15-3 in early-stage breast cancer
Fluorizoline bind to prohibitin (显示 PHB 抗体), inducing mitochondrial apoptotic pathway through NOXA (显示 PMAIP1 抗体) and BIM (显示 BCL2L11 抗体) upregulation.
REA modulates cross talk among multiple cell types in the uterine tissue and host background, serving as a brake on the estradiol-ER axis and restraining multiple aspects that contribute to the pathologic progression of endometriosis.
BIG3 (显示 WDR5 抗体) may block the KPNAs (KPNA1 (显示 KPNA1 抗体), KPNA5 (显示 KPNA5 抗体), and KPNA6 (显示 KPNA6 抗体)) binding region(s) of PHB2.
results show that PHB2 binds to the ligand binding domain of ERalpha (显示 ESR1 抗体) with a conformational change in the helix 12 of ERalpha (显示 ESR1 抗体)
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (显示 HNRNPD 抗体), PHB2 and UB2V2 (显示 UBE2V2 抗体) can increase HCMV replication, while knockdown of A4 and KSRP (显示 KHSRP 抗体) resulted in decreased HCMV replication.
These results demonstrate that estradiol upregulates REA expression and recruits REA via ERalpha (显示 ESR1 抗体) to the EREs on the RORgammaT promoter region, thus inhibiting RORgammaT expression and Th17 differentiation.
BIG3 (ARFGEF3) is predicted to interact with its partner PHB2 through an ARM-type alpha-helical structure.
Data indicate that the up-regulated expression of prohibitin (显示 PHB 抗体) promoted acute promyelocytic leukemia (显示 PML 抗体) cell line NB4-R1 cell apoptosis.
CARL can suppress mitochondrial fission and apoptosis by targeting miR (显示 MLXIP 抗体)-539 and PHB2.
results suggest that PHB2 is a crucial mitochondrial regulator for homeostasis and lineage-specific differentiation of ES cells.
Loss of PHB2 impairs the stability of OPA1 (显示 MED12 抗体), affects mitochondrial ultrastructure, and induces the perinuclear clustering of mitochondria in hippocampal neurons
REA physiologically restrains endometrial stromal cell decidualization, controlling the timing and magnitude of decidualization to coordinate uterine differentiation with concurrent embryo development that is essential for implantation and fertility.
PHB1 (显示 PHB 抗体) and PHB2 are critical mediators in promoting 3T3-L1 adipocyte differentiation and may be the potential targets for obesity therapies
Optimal uterine development and functional activities require the normal gene dosage of REA, with partial or complete deletion resulting in hyperresponsiveness or underresponsiveness to hormone and subfertility or infertility, respectively.
Serine phosphorylation of PHB2 by CaMK IV (显示 CAMK4 抗体) relieves its inhibition on MEF2 (显示 MEF2C 抗体).
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity).
B-cell receptor-associated protein 37
, prohibitin 2
, B-cell associated protein
, B-cell receptor-associated protein BAP37
, repressor of estrogen receptor activity
, B-cell receptor associated protein 37