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Rat (Rattus) IAPP ELISA Kit for Competition ELISA - ABIN431403
El Assar, Angulo, Santos-Ruiz, Moreno, Novials, Villanueva-Peñacarrillo, Rodríguez-Mañas: Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats. in PLoS ONE 2015
All-atom explicit-water molecular dynamics (MD) simulations studying adsorption, orientation, and surface interaction of hIAPP aggregates with different sizes (monomer to tetramer) and conformations (monomer with alpha-helix and tetramer with beta-sheet-rich U-turn) upon adsorption. hIAPP monomer with alpha-helical conformation and hIAPP pentamer with beta-sheet conformation can adsorb on both POPC and POPC/POPE (显示 HMBS ELISA试剂盒) bilayers.
Data (including data from studies using tissues from transgenic mice) suggest that IL1B (显示 IL1B ELISA试剂盒) plays dual roles by (1) mediating islet amyloid-induced FAS (显示 FAS ELISA试剂盒) up-regulation and apoptosis in pancreatic beta-cells and (2) down-regulating IAPP precursor processing thereby potentiating islet amyloid formation. (IL1B (显示 IL1B ELISA试剂盒) = interleukin-1beta; FAS (显示 FAS ELISA试剂盒) = FAS (显示 FAS ELISA试剂盒) cell surface death receptor; IAPP = islet amyloid polypeptide)
Data suggest that single aromatic/hydrophobic amino acid residues within IAPP (islet amyloid polypeptide) amyloid core region are able to control its interaction with amyloid-beta(1-40) or amyloid-beta(1-42) but not IAPP self-assembly; four aromatic/hydrophobic residues are able to control both IAPP amyloid self-assembly and its cross-interaction with amyloid-beta(1-40) or amyloid-beta(1-42).
Data show that aluminum (Al3+) could inhibit islet amyloid polypeptide hIAPP(11-28) fibrillogenesis.
The absence of BACE2 (显示 BACE2 ELISA试剂盒) ameliorates glucose tolerance defects induced by IAPP overexpression in the beta-cell and promotes beta-cell survival.
This study supports the elucidation of the structural basis of IAPP amyloid formation and highlights the extent of amyloid fibril polymorphism.
Data suggest that a single GlcNAc residue at CTR (显示 CALCR ELISA试剂盒) N130 (asparagine 130) is responsible for enhanced affinity of calcitonin (显示 CALCA ELISA试剂盒) for CTR (显示 CALCR ELISA试剂盒) ECD (显示 SHFM1 ELISA试剂盒); the same appears to apply for enhanced affinity of amylin for RAMP2 (显示 RAMP2 ELISA试剂盒)-CTR (显示 CALCR ELISA试剂盒) ECD (显示 SHFM1 ELISA试剂盒). [GlcNAc = N-acetylglucosamine; CTR (显示 CALCR ELISA试剂盒) = calcitonin receptor (显示 CALCR ELISA试剂盒); ECD (显示 SHFM1 ELISA试剂盒) = extracellular domain; RAMP2 (显示 RAMP2 ELISA试剂盒) = receptor (calcitonin) activity modifying protein 2 (显示 RAMP2 ELISA试剂盒)].
The kinetics of human amylin amyloid formation can be monitored by SYPRO-orange fluorescence and match the time course determined with thioflavin-T assays.
effect of cholesterol on the amyloidogenicity of IAPP
Chondroitin sulfate A has an intensive promotion effect on the fibrillation of human IAPP at the palmitoyloleoylphosphatidylcholine (POPC) membrane, which is larger than the total effect of Chondroitin sulfate A alone and POPC alone.
These data suggest participation by both soluble and fibrillar aggregates in IAPP-induced islet inflammation. IAPP-induced activation of TLR2 (显示 TLR2 ELISA试剂盒) and secretion of IL-1 (显示 IL1A ELISA试剂盒) may be important therapeutic targets to prevent amyloid-associated beta cell dysfunction.
Hypothalamic amylin is transcriptionally regulated by leptin (显示 LEP ELISA试剂盒), that it can act directly on ObRb (显示 LEPR ELISA试剂盒) neurons in concert with leptin (显示 LEP ELISA试剂盒), and that it regulates feeding.
Matrix Metalloproteinase-9 (显示 MMP9 ELISA试剂盒) Protects Islets from Amyloid-induced Toxicity.
Data indicate that T-cell receptors that react to chromogranin A (ChgA (显示 CHGA ELISA试剂盒)) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (显示 PRSS16 ELISA试剂盒)).
Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin (显示 INS ELISA试剂盒) upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells.
deletion of the DeltaN isoforms of p63 (显示 CKAP4 ELISA试剂盒) or p73 (显示 ARHGAP24 ELISA试剂盒) leads to metabolic reprogramming and regression of p53 (显示 TP53 ELISA试剂盒)-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin (显示 INS ELISA试剂盒) by the beta cells of the pancreas
The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated.
studies have identified a novel TXNIP (显示 TXNIP ELISA试剂盒)/miR (显示 MLXIP ELISA试剂盒)-124a/FoxA2 (显示 FOXA2 ELISA试剂盒)/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP (显示 TXNIP ELISA试剂盒) and IAPP
MMP-9 (显示 MMP9 ELISA试剂盒) constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP.
Data suggest that amylin and leptin (显示 LEP ELISA试剂盒) play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress.
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Islet amyloid polypeptide (diabetes-associated peptide; amylin)
, diabetes-associated peptide
, insulinoma amyloid peptide
, islet amyloid polypeptide
, amyloid protein