(Heart and Neural Crest Derivatives Expressed 2 (HAND2))
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008].
Cho, Okada, Tsuzuki, Nishigaki, Yasuda, Kanzaki: "Progestin-induced heart and neural crest derivatives expressed transcript 2 is associated with fibulin-1 expression in human endometrial stromal cells." in: Fertility and sterility, Vol. 99, Issue 1, pp. 248-55, (2012) (PubMed).
Lucas, Müller, Rüdiger, Henion, Rohrer: "The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons." in: Development (Cambridge, England), Vol. 133, Issue 20, pp. 4015-24, (2006) (PubMed).
McFadden, Charité, Richardson, Srivastava, Firulli, Olson: "A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart." in: Development (Cambridge, England), Vol. 127, Issue 24, pp. 5331-41, (2001) (PubMed).