ErbB2/Her2 抗体
(Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
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Latest Publications for our ErbB2/Her2 抗体
: "The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity." in: Nature communications, Vol. 9, Issue 1, pp. 3049, (2019) (PubMed).: "Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma." in: Neuro-oncology, Vol. 20, Issue 4, pp. 506-518, (2019) (PubMed).
: "An Organoid-Based Preclinical Model of Human Gastric Cancer." in: Cellular and molecular gastroenterology and hepatology, Vol. 7, Issue 1, pp. 161-184, (2019) (PubMed).
: "Potent Antitumor Activity of Liposomal Irinotecan in an Organoid- and CRISPR-Cas9-Based Murine Model of Gallbladder Cancer." in: Cancers, Vol. 11, Issue 12, (2019) (PubMed).
: "Single nucleotide variant profiles of viable single circulating tumour cells reveal CTC behaviours in breast cancer." in: Oncology reports, Vol. 39, Issue 5, pp. 2147-2159, (2018) (PubMed).
: "GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2." in: Journal of experimental & clinical cancer research : CR, Vol. 37, Issue 1, pp. 80, (2018) (PubMed).
: "ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 15, pp. E3129-E3138, (2018) (PubMed).
: "Aberrant Signaling through the HER2-ERK1/2 Pathway is Predictive of Reduced Disease-Free and Overall Survival in Early Stage Non-Small Cell Lung Cancer (NSCLC) Patients." in: Journal of Cancer, Vol. 8, Issue 2, pp. 227-239, (2017) (PubMed).
: "Development of a highly specific HER2 monoclonal antibody for immunohistochemistry using protein microarray chips." in: Biochemical and biophysical research communications, Vol. 484, Issue 2, pp. 248-254, (2017) (PubMed).
: "HER2/ERBB2 immunoreactivity in human retinoblastoma." in: Tumour biology, Vol. 37, Issue 5, pp. 6135-42, (2016) (PubMed).
Aliases for ErbB2/Her2 抗体
erb-b2 receptor tyrosine kinase 2 (ERBB2) 抗体erb-b2 receptor tyrosine kinase 2 (Erbb2) 抗体
erb-b2 receptor tyrosine kinase 2 (erbb2) 抗体
c-erbB2 抗体
c-neu 抗体
CD340 抗体
erb2 抗体
Erbb-2 抗体
HER-2 抗体
HER-2/neu 抗体
HER2 抗体
mKIAA3023 抗体
MLN 19 抗体
NEU 抗体
Neu 抗体
NGL 抗体
TKR1 抗体
wu:fv70f10 抗体
zgc:63601 抗体
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