This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012].
Perna, Karreth, Rust, Perez-Mancera, Rashid, Iorio, Alifrangis, Arends, Bosenberg, Bollag, Tuveson, Adams: "BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 6, pp. E536-45, (2015) (PubMed).
Kameda, Thomson: "Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript." in: Stem cells (Dayton, Ohio), Vol. 23, Issue 10, pp. 1535-40, (2005) (PubMed).
Takahashi, Mitsui, Yamanaka: "Role of ERas in promoting tumour-like properties in mouse embryonic stem cells." in: Nature, Vol. 423, Issue 6939, pp. 541-5, (2003) (PubMed).
Aliases for ERAS 抗体
ES cell expressed Ras (ERAS) 抗体 ES cell expressed Ras (Eras) 抗体 ES cell-expressed Ras (Eras) 抗体 ecat5 抗体 Ha-Ras2 抗体 HRAS2 抗体 HRASP 抗体 HRasp 抗体