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ELANE 产品

(Elastase, Neutrophil Expressed (ELANE))
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].

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Featured ELANE Categories

ELANE 抗体

High quality antibodies with extensive validation data.

ELANE ELISA试剂盒

Reliable ELISA kits for a wide range of species.

ELANE 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ELANE 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF
Validations
  • (7)
Cat. No. ABIN6140110
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Monkey
Application WB, ELISA, IHC, FACS, ICC, Neut
Validations
  • (6)
Cat. No. ABIN5611333
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7431269
Quantity 100 μL
Datasheet Datasheet

Recommended ELANE ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6955518
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955517
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6955519
Quantity 96 tests
Datasheet Datasheet

Recommended ELANE 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1352646
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3079274
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3122112
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our ELANE Products

Bolatchiev, Baturin, Bazikov, Maltsev, Kunitsina: "Effect of antimicrobial peptides HNP-1 and hBD-1 on Staphylococcus aureus strains in vitro and in vivo." in: Fundamental & clinical pharmacology, Vol. 34, Issue 1, pp. 102-108, (2020) (PubMed).

Zhang, Qiu, Tang, Zhou, Zhang, He, Bai, Li, Deng, Liang, Zhong: "Erythromycin suppresses neutrophil extracellular traps in smoking-related chronic pulmonary inflammation." in: Cell death & disease, Vol. 10, Issue 9, pp. 678, (2020) (PubMed).

Rivera-Franco, Leon-Rodriguez, Torres-Ruiz, Gómez-Martín, Angles-Cano, de la Luz Sevilla-González: "Neutrophil Extracellular Traps Associate with Clinical Stages in Breast Cancer." in: Pathology oncology research : POR, Vol. 26, Issue 3, pp. 1781-1785, (2020) (PubMed).

Gu, Wen, Lu, Zhang, Wang, Du, Zeng, Jiang: "MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes." in: Journal of clinical immunology, Vol. 40, Issue 1, pp. 147-157, (2020) (PubMed).

He, Lu, Song, Gong, Li: "Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats." in: Bioscience reports, Vol. 39, Issue 12, (2020) (PubMed).

Yao, Han, Guan, Guan, Wu, Chen, Li, Hei: "Neutrophil Elastase Inhibitors Suppress Oxidative Stress in Lung during Liver Transplantation." in: Oxidative medicine and cellular longevity, Vol. 2019, pp. 7323986, (2020) (PubMed).

Duruel, Berker, Özşin-Özler, Gharibzadeh-Hızal, Gürpınar, Eryılmaz-Polat, Ataman-Duruel, Tan, Karabulut, Tekçiçek, Eser, Kiper, Tezcan: "Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis." in: Cytokine, Vol. 127, pp. 154987, (2020) (PubMed).

Ma, Wang, Song, Li, Li, Dou, Xie, Zhou: "Corneal epithelial injury-induced norepinephrine promotes Pseudomonas aeruginosa keratitis." in: Experimental eye research, Vol. 195, pp. 108048, (2020) (PubMed).

Lian, Xu, Wang, Wang, Li, Yao, Ji, Wang, Guo, Li, Yang: "Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats." in: Behavioural brain research, Vol. 359, pp. 304-311, (2019) (PubMed).

Yu, Wei, Weiss, Felder: "Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats." in: Neuroscience, Vol. 381, pp. 46-58, (2019) (PubMed).

Synonyms and alternative names related to ELANE

elastase, neutrophil expressed (ELANE), elastase, neutrophil expressed (Elane), proteinase 3 (prtn3), ELA2, Ela2, ela2, ELANE, F430011M15Rik, GE, HLE, HNE, NE, PMN-E, SCN1

Protein level used designations for ELANE

  • PMN elastase
  • bone marrow serine protease
  • elastase 2, neutrophil
  • elastase-2
  • granulocyte-derived elastase
  • human leukocyte elastase
  • leukocyte elastase
  • medullasin
  • neutrophil elastase
  • polymorphonuclear elastase
  • serine protease
  • elastase, neutrophil expressed
  • LOW QUALITY PROTEIN: neutrophil elastase
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