EIF4G2 产品
(Eukaryotic Translation Initiation Factor 4 gamma 2 (EIF4G2))
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Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3\; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].
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Featured EIF4G2 Categories
Recommended EIF4G2 抗体
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Reactivity
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ABIN3016941
Quantity
100 μL
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Reactivity
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Cat. No.
ABIN2855137
Quantity
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Datasheet
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Reactivity
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Cat. No.
ABIN560721
Quantity
100 μg
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Latest Publications for our EIF4G2 Products
: "The mammalian host protein DAP5 facilitates the initial round of translation of Coxsackievirus B3 RNA." in: The Journal of biological chemistry, Vol. 294, Issue 42, pp. 15386-15394, (2019) (PubMed).: "The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 12, pp. 3585-601, (2014) (PubMed).
: "Thyroid hormone increases bulk histones expression by enhancing translational efficiency." in: Molecular endocrinology (Baltimore, Md.), Vol. 29, Issue 1, pp. 68-75, (2014) (PubMed).
: "Amino acid availability and age affect the leucine stimulation of protein synthesis and eIF4F formation in muscle." in: American journal of physiology. Endocrinology and metabolism, Vol. 293, Issue 6, pp. E1615-21, (2007) (PubMed).
: "A new translational regulator with homology to eukaryotic translation initiation factor 4G." in: The EMBO journal, Vol. 16, Issue 4, pp. 817-25, (1997) (PubMed).
: "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme." in: Genes & development, Vol. 11, Issue 3, pp. 321-33, (1997) (PubMed).
Synonyms and alternative names related to EIF4G2
eukaryotic translation initiation factor 4 gamma 2 (EIF4G2), eukaryotic translation initiation factor 4, gamma 2b (eif4g2b), eukaryotic translation initiation factor 4, gamma 2 (Eif4g2), eukaryotic translation initiation factor 4 gamma, 2 (EIF4G2), eIF4G-related protein NAT1 (nat1), eukaryotic translation initiation factor 4 gamma 2 (Eif4g2), eukaryotic translation initiation factor 4, gamma 2a (eif4g2a), eukaryotic translation initiation factor 4 gamma, 2 S homeolog (eif4g2.S), AA589388, AAG1, DAP-5, DAP5, dap5, E130105L11Rik, eif4g2, EIF4G2, eif4g2.L, hm:zeh1307, im:7148615, NAT1, Nat1, nat1, NAT1A, NAT1B, Natm1, P97, p97, wu:fa14h01, wu:fb44h01, wu:fb59c06, wu:fb81f07, wu:fb82b06, wu:fb98h08, wu:fc21b05Protein level used designations for EIF4G2
- DAP-5
- aging-associated protein 1
- death-associated protein 5
- eIF-4-gamma 2
- eIF-4G 2
- eIF4G 2
- eukaryotic translation initiation factor 4 gamma 2
- eukaryotic translation initiation factor 4G-like 1
- p97
- novel APOBEC-1 target 1
- translation repressor NAT1
- eukaryotic translation initiation factor 4 gamma, 2
- fb44h01
- Eukaryotic translation initiation factor 4 gamma 2
- translation repressor Nat1
- eIF4G-related protein NAT1
- eIF4G-related protein NAT1A
- eukaryotic translation initiation factor 4, gamma 2a
- eukaryotic translation initiation factor 4 gamma, 2 L homeolog
- eukaryotic translation initiation factor 4 gamma, 2 S homeolog
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