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抗Rat (Rattus) PTK2B 抗体:
抗Mouse (Murine) PTK2B 抗体:
抗Human PTK2B 抗体:
Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177155
Anand, Cucchiarini, Terwilliger, Ganju: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177156
Faure, Corvol, Toutant, Valjent, Hvalby, Jensen, El Messari, Corsi, Kadaré, Girault: Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons. in Journal of cell science 2007
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Human PTK2B Primary Antibody for IHC - ABIN966926
Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004
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Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705
Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004
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Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN966925
: Fresh concepts in dental design. in Journal of the California Dental Association 2004
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Human Polyclonal PTK2B Primary Antibody for IF (p), IHC (p) - ABIN745763
Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015
Human Polyclonal PTK2B Primary Antibody for ICC, IF - ABIN257536
Lu, Chen, Shimoda, Park, Zhang, Tran, Zhang, Semenza: Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. in Cell reports 2017
Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362858
Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001
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Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362252
Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012
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both AKT phosphorylation and RAC-dependent membrane ruffling were markedly reduced by depletion of either APPL1 or MYO6. These results place MYO6 and its binding partners at a central nexus in cellular signaling linking actin dynamics at the cell surface and endosomal signaling in the cell cortex.
TXNIP (显示 TXNIP 抗体) is a direct substrate of protein kinase B (AKT (显示 AKT1 抗体)) and is responsible for mediating AKT (显示 AKT1 抗体)-dependent acute glucose influx after growth factor stimulation.
Influence of 1mM MbetaCD on the fenoterol-driven changes in both contractility and NO level was strongly attenuated by inhibition of Gi-protein (pertussis toxin), Akt (Akt 1 (显示 AKT1 抗体)/2 kinase inhibitor) or NO-synthase (显示 NOS 抗体) (L-NAME)..Obtained results suggest that slight cholesterol depletion upregulates Gi-protein/Akt (显示 AKT1 抗体)/NO-synthase (显示 NOS 抗体) signaling that attenuates the positive inotropic response to b2-adrenergic stimulation
Akt1 (显示 AKT1 抗体) conditions the normal circadian rhythm in the vasculature more so than in other peripheral tissues where other AKT (显示 AKT1 抗体) isoforms or kinases might be important for daily rhythms.
UVB-irradiated or aged mice skin revealed that mTORC2 (显示 CRTC2 抗体) activity was significantly upregulated which in turn increased Akt (显示 AKT1 抗体) activation and Akt (显示 AKT1 抗体)-dependent IkappaB kinase alpha (显示 CHUK 抗体) (IKKalpha (显示 CHUK 抗体)) phosphorylation, and The increased mTORC2 (显示 CRTC2 抗体) signaling pathway during skin aging were associated to NF-kappaB (显示 NFKB1 抗体) activation.
this study reveals the function of IL-15 (显示 IL15 抗体) in astrocyte survival via Akt (显示 AKT1 抗体) phosphorylation in response to OGD (显示 FGFR1 抗体)-induced damage.
This study demonstrates the neuroprotective effect of TSG (显示 TWSG1 抗体) on APP (显示 APP 抗体) expression, suggesting that TSG (显示 TWSG1 抗体) may be beneficial for AD prevention and treatment.
Data show that NEDL2 regulates GDNF/Ret/Akt pathway depends on its Nedd8 ligase activity rather than ubiquitin ligase activity.
Despite higher endogenous insulin (显示 INS 抗体) concentrations following feeding, arcuate nucleus phosphorylation of Akt (pAkt (显示 AKT1 抗体)) levels were significantly lower in the pregnant group compared with the nonpregnant group.
Setdb1 (显示 SETDB1 抗体) regulates PTEN/AKT (显示 AKT1 抗体)/FOXO1 (显示 FOXO1 抗体) pathway to inhibit Spermatogonial stem cells apoptosis.
thrombin (显示 F2 抗体) binding to PAR-1 (显示 MARK2 抗体) receptor activated Gi-protein/c (显示 PROC 抗体)-Src (显示 SRC 抗体)/Pyk2/EGFR (显示 EGFR 抗体)/PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体)/p42/p44 (显示 PSMC6 抗体) MAPK (显示 MAPK3 抗体) cascade, which in turn elicited AP-1 (显示 FOSB 抗体) activation and ultimately evoked MMP-9 (显示 MMP9 抗体) expression and cell migration in SK-N-SH cells.
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
In summary, our data suggested that PYK2 via S6K1 (显示 RPS6KB1 抗体) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (显示 RPS6KB1 抗体) may potentially serve as therapeutic targets for PCa (显示 FLVCR1 抗体) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (显示 CTNNB1 抗体) in the crosstalk between Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) and Wnt (显示 WNT2 抗体)/Ca(2 (显示 CA2 抗体)+) signaling pathways upon Wnt3a (显示 WNT3A 抗体) stimulation in differentiating hNPCs.
STIM1 (显示 STIM1 抗体)-induced Ca(2 (显示 CA2 抗体)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (显示 PTPRB 抗体) and VE-cadherin (显示 CDH5 抗体) and hence increase endothelial permeability.
Ascites and CCL18 (显示 CCL18 抗体) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin (显示 0 抗体), a process in part mediated through the PI3-kinase (显示 PIK3CA 抗体)-Akt/PKB (显示 AKT1 抗体) cell survival pathway. These results provide further rationale for clinical investigation of relaxin (显示 0 抗体) as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Studies suggest that PYK2 is a common downstream effector of ErbB (显示 EGFR 抗体) and IL8 (显示 IL8 抗体) receptors, and that PYK2 integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.
Pyk2 is a key downstream signaling molecules of CCR7 (显示 CCR7 抗体) in SCCHN, which promotes SCCHN tumorigenesis and progression.
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, PKB alpha
, RAC protein kinase alpha RAC-PK alpha
, RAC-alpha serine/threonine-protein kinase
, murine thymoma viral (v-akt) oncogene homolog 1
, protein kinase B alpha
, thymoma viral proto-oncogene 1
, protein kinase B-alpha
, proto-oncogene c-AKT
, related to A and C kinases
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta