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抗Human PTK2B 抗体:
抗Mouse (Murine) PTK2B 抗体:
抗Rat (Rattus) PTK2B 抗体:
Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177156
Anand, Cucchiarini, Terwilliger, Ganju: The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. in Journal of immunology (Baltimore, Md. : 1950) 2008
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Human Monoclonal PTK2B Primary Antibody for ICS - ABIN1177155
Avraham, Park, Schinkmann, Avraham: RAFTK/Pyk2-mediated cellular signalling. in Cellular signalling 2000
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Human PTK2B Primary Antibody for IHC - ABIN966926
Gluck: Acid sensing in renal epithelial cells. in The Journal of clinical investigation 2004
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Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN1724705
Dylla, Deyle, Theunissen, Padurean, Verfaillie: Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. in Experimental hematology 2004
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Human Polyclonal PTK2B Primary Antibody for ICC, IF - ABIN257536
Lu, Chen, Shimoda, Park, Zhang, Tran, Zhang, Semenza: Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment. in Cell reports 2017
Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362252
Tomomura, Hasegawa, Suda, Sakagami, Tomomura et al.: Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ... in The Journal of biological chemistry 2012
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Human Polyclonal PTK2B Primary Antibody for IF, IHC - ABIN362858
Benzing, Gerke, Höpker, Hildebrandt, Kim, Walz: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2. in Proceedings of the National Academy of Sciences of the United States of America 2001
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Human Polyclonal PTK2B Primary Antibody for IF (p), IHC (p) - ABIN745763
Cao, Zheng, Wang, Wang, Li, Li, Lai, Wang, Qin: Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. in Bone 2015
Human Monoclonal PTK2B Primary Antibody for IHC, ELISA - ABIN966925
: Fresh concepts in dental design. in Journal of the California Dental Association 2004
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Results show that VEGFA (显示 VEGFA 抗体) induces Pyk2 activation in mediating human retinal microvascular endothelial cell migration, sprouting and tube formation, and that Pyk2-mediated STAT3 (显示 STAT3 抗体) activation is required for hypoxia-induced retinal neovascularization.
Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2 (显示 EPHX2 抗体)); both of which have been previously associated with AD as risk factors.
thrombin (显示 F2 抗体) binding to PAR-1 (显示 MARK2 抗体) receptor activated Gi-protein/c (显示 PROC 抗体)-Src (显示 SRC 抗体)/Pyk2/EGFR (显示 EGFR 抗体)/PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体)/p42/p44 (显示 PSMC6 抗体) MAPK (显示 MAPK3 抗体) cascade, which in turn elicited AP-1 (显示 FOSB 抗体) activation and ultimately evoked MMP-9 (显示 MMP9 抗体) expression and cell migration in SK-N-SH cells.
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
In summary, our data suggested that PYK2 via S6K1 (显示 RPS6KB1 抗体) activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 and S6K1 (显示 RPS6KB1 抗体) may potentially serve as therapeutic targets for PCa (显示 FLVCR1 抗体) treatment.
Our findings suggest that Pyk2 plays an important role in the coordination of stabilization of beta-catenin (显示 CTNNB1 抗体) in the crosstalk between Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) and Wnt (显示 WNT2 抗体)/Ca(2 (显示 CA2 抗体)+) signaling pathways upon Wnt3a (显示 WNT3A 抗体) stimulation in differentiating hNPCs.
STIM1 (显示 STIM1 抗体)-induced Ca(2 (显示 CA2 抗体)+) signaling activates Pyk2 to inhibit the interaction of VE-PTP (显示 PTPRB 抗体) and VE-cadherin (显示 CDH5 抗体) and hence increase endothelial permeability.
Ascites and CCL18 (显示 CCL18 抗体) stimulate the phosphorylation and expression of Pyk2, which positively regulates ascites-induced ovarian cancer cell migration.
We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin (显示 0 抗体), a process in part mediated through the PI3-kinase (显示 PIK3CA 抗体)-Akt/PKB (显示 AKT1 抗体) cell survival pathway. These results provide further rationale for clinical investigation of relaxin (显示 0 抗体) as a potential therapeutic in preeclampsia.
PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.
Data provide evidence that activated PYK2 may function as a component of the microtubule organizing center to regulate spindle assembly during the meiotic process of mouse oocytes.
MMP-9 (显示 MMP9 抗体) activation by hypoxia requires LRP1 (显示 LRP1 抗体) and Pyk2 phosphorylation in fibroblasts.
results suggest that although Pyk2 and FAK (显示 PTK2 抗体) are involved in inflammasome activation, only Pyk2 directly phosphorylates ASC (显示 STS 抗体) and brings ASC (显示 STS 抗体) into an oligomerization-competent state by allowing Tyr146 phosphorylation to participate ASC (显示 STS 抗体) speck formation and subsequent NLRP3 (显示 NLRP3 抗体) inflammation.
Osteoprotegerin (显示 TNFRSF11B 抗体) may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 and Src (显示 SRC 抗体) and their intracellular distribution in osteoclasts.
These results suggest that mechanical stimuli activate P2X7 (显示 P2RX7 抗体) might induce ECMPs expression through PYK2 except in the case of OPN (显示 SPP1 抗体) expression. Altogether, mechanical stimuli-induced ECMPs production might be implicated by extracellular ATP secretion or integrin via PYK2 activation.
Lineage-tracing of monocyte populations suggests that Pyk2 promotes apoptosis in BM monocytes, thereby acting as an important homeostatic regulator of turnover in these short-lived, innate immune cells.
Pyk2 selectively contributes to the coordination of phagocytosis-promoting signals downstream of CR3 (显示 ITGAM 抗体), but is dispensable for FcgammaR-mediated phagocytosis
the findings suggest a model in which the oocyte is not a passive participant in fertilization, but instead responds to sperm contact by localized PYK2 signaling that promotes actin remodeling events required to physically incorporate the sperm head into the ooplasm (显示 NLRP5 抗体).
results show that Pyk2 contributes to cytotoxic T lymphocyte(CTL) migration by regulating detachment of CTL at the trailing edge, which could explain why Pyk2 is important for chemotactic and migratory responses.
Defects in Pyk2 suppress Kawasaki Disease-like experimental vasculitis, presumably through CXCL9 (显示 CXCL9 抗体)- and CXCL10 (显示 CXCL10 抗体)-dependent interference with neo-angiogenesis. Since Pyk2-KO mice show no life-threatening phenotype, Pyk2 may be a promising therapeutic molecular target for KD.
Ptk2b activation may play a key role in the signaling responses in ECs under hemodynamic influence [proline-rich tyrosine kinase 2]
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
, FADK 2
, PTK2B protein tyrosine kinase 2 beta
, calcium-dependent tyrosine kinase
, calcium-regulated non-receptor proline-rich tyrosine kinase
, cell adhesion kinase beta
, focal adhesion kinase 2
, proline-rich tyrosine kinase 2
, protein kinase B
, protein-tyrosine kinase 2-beta
, related adhesion focal tyrosine kinase
, cellular adhesion kinase beta
, protein tyrosine kinase 2 beta
, CAK beta
, PTK2 protein tyrosine kinase 2 beta
, protein tyrosine kinase 2.2
, protein tyrosine kinase 2aa
, protein tyrosine kinase 2b