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抗Human RMI2 抗体:
In both patient and knockout cell lines reduced localisation of BLM to ultra fine DNA bridges and FANCD2 at foci linking bridges are observed. Overall, loss of RMI2 produces a partially active BLM complex with mild features of Bloom syndrome.
The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex.
two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner.
Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex
RMI2 is a component of the BLM (RECQL3\; MIM 604610) complex, which plays a role in homologous recombination-dependent DNA repair and is essential for genome stability (Xu et al., 2008
BLM-associated protein of 18 kDa
, RMI2, RecQ mediated genome instability 2, homolog
, RecQ-mediated genome instability 2, S. cerevisiae, homolog of
, recQ-mediated genome instability protein 2