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OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
Our results support the hypotheses that those who develop PC have significantly higher level of genomic instability which is further increased in those who carry G allele of the hOGG1 (C1245G) polymorphism.
The methylation status of XRCC1 (methylated at T0) and hOGG1 (unmethylated at T0) remained unchanged in the three sampling times. In conclusion, this study showed modulations of hOGG1 and XRCC1 expression especially 1 day after elective surgery in patients undergoing PROP and ISO anaesthesia
The processing of the lesions was evaluated by purified enzyme cocktails of hNTH1 and hOGG1 as well as with a HeLa cell extract. Interestingly, the yield of double-strand breaks (DSBs) resulting from the processing of the bistranded lesions are appreciably lower when the DNA is treated with the HeLa cell extract compared with the relevant purified enzyme cocktail in both models
study concludes that Ser326Cys polymorphism of the OGG1 gene may modulate the risk of colorectal cancer by increasing the level of oxidative DNA damage
Results provide evidence that OGG1 rs1052133 is significantly associated with Wilms tumor susceptibility.
TNF-alpha - Reactive Oxygen Species -driven enrichment of OGG1 at gene regulatory regions in the chromatinized DNA, which is a prerequisite to modulation of gene expression for prompt cellular responses to oxidant stress.
OGG1 S326C polymorphism increases probability of AML relapse and may be useful as a prognostic factor for AML relapse risk.
This study identifies patient's carrying the OGG1 Ser326Cys CC genotype are at greater risk for HIV associated low birth weight, and delivering prematurely.
Of 39 subfertile men, 74.4% (29/39) had the hOGG1 Cys/Cys genotype. Patients in groups 1 and 2 with hOGG1 Cys/Cys genotype had significantly higher 8-OHdG content in sperm DNA, lower mitochondrial copy number in spermatozoa and lower TAC in seminal plasma than those with Ser/Ser or Ser/Cys genotype.
CDK4/6 inhibitors also lead to accumulation of DNA damage by repressing PARP1 in oxidatively stressed cells. Thus, CDK4/6 inhibitors sensitize G1-arrested cells to anticancer drugs, since these cells require PARP1-OGG1 functional interaction for cell survival
OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR-200a and its expression levels significantly decrease in aged keratinocytes.
The level of OGG1 expression was significantly reduced in bipolar patients compared to healthy individuals, whereas the two groups exhibited similar levels of NEIL1 expression.
Results identified a significant relationship between SNP rs13181 of OGG1 and an increased risk of endometrial cancer development.
The OGG1 gene presents downregulation in the more advanced stages of colorectal cancer
OGG1 gene Ser326Cys polymorphism was associated with age-related cataract risk (meta-analysis and review).
Miners with the G/G genotype of the OGG1 (rs1052133) gene had an increased frequency of binucleated lymphocytes with micronuclei compared to the C/C genotype carriers. In addition, three-locus model of gene-gene interactions OGG1 (rs1052133) * ADPRT (rs1136410) * XRCC4 (rs6869366) was associated with high genotoxic risk in coal miners.
Human Ogg1 removes 7,8-dihydro-8-oxoguanine (OG) paired with cytosine (C) but is inactive toward the OG:adenine (A) pair. In contrast, Geobacillus stearothermophilus Formamidopyrimidine-DNA Glycosylase removes OG from OG:C pairs and also exhibits appreciable (although diminished) activity toward OG:A pairs.
For several turns of the helix, Authors observe that solution accessible 8-oxoGs are sites of activity for hOGG1. At the dyad axis, however, hOGG1 activity is suppressed, even at lesions predicted to be solution accessible by hydroxyl radical footprinting (HRF).
The present meta-analysis concluded that the G allele was associated with an increased risk of cancer. It suggested that the hOGG1 polymorphism may be a candidate marker of cancer.
hOGG1 mRNA is downregulated in non-small cell lung cancer tissues. Methylated +322-327 CpG site in the hOGG1 5'-UTR is associated with reduced expression of hOGG1 by decreasing the recruitment of Sp1 to the 5'-UTR of hOGG1 in A549 cells.
OGG1 affects PRMT5 binding on histone H4 and the formation of dimethylation of histone H4 arginine-3 via PRMT5.
This study demonstrated that the heterozygous Ogg1+/- mice exhibited poorer learning performance in the Barnes maze and Restoration by X-ray Irradiation.
These observations imply that pre-excision step(s) during OGG1 initiated base excision repair evoked by reactive oxygen species facilitates NF-kappaB DNA occupancy and gene expression.
Me-Pa toxicity alters Ogg1 and Nrf2 promoter methylation.
we show for the first time that OGG1 plays a distinct role in regulation of blood hepatic glucose production.
Data show that the total liver tumors was significantly higher in the N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH)-administered oxoguanine glycosylase 1 (Ogg1) knockout (-)(/)(-) males and females.
8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced DNA demethylation.
OGG1 plays a role in an LSD1-dependent pathway of LPS-induced macrophage activation in mice.
These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury.
These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.
DNA repair protein OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB and functions in epigenetic regulation of gene expression.
OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation.
OGG1 acts as a STAT1 coactivator and has transcriptional activity in the presence of endotoxin
Ogg1 and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation.
Deletion of one or both alleles of ogg1 in mice does increase susceptibility to the toxic effects of aflatoxin B1.
OGG1- DNA base excision repair plays a role in various biological processes that may benefit the host, but when in excess could be implicated in disease and/or aging processes.
Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism.
rise in the intracellular 8-oxoG base levels increases the proportion of GTP-bound Rac1
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f