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OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (显示 ARFRP1 蛋白) in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
Miners with the G/G genotype of the OGG1 (rs1052133) gene had an increased frequency of binucleated lymphocytes with micronuclei compared to the C/C genotype carriers. In addition, three-locus model of gene-gene interactions OGG1 (rs1052133) * ADPRT (显示 PARP1 蛋白) (rs1136410) * XRCC4 (显示 XRCC4 蛋白) (rs6869366) was associated with high genotoxic risk in coal miners.
Human Ogg1 removes 7,8-dihydro-8-oxoguanine (OG) paired with cytosine (C) but is inactive toward the OG:adenine (A) pair. In contrast, Geobacillus stearothermophilus Formamidopyrimidine-DNA Glycosylase removes OG from OG:C pairs and also exhibits appreciable (although diminished) activity toward OG:A pairs.
For several turns of the helix, Authors observe that solution accessible 8-oxoGs are sites of activity for hOGG1. At the dyad axis, however, hOGG1 activity is suppressed, even at lesions predicted to be solution accessible by hydroxyl radical footprinting (HRF (显示 TPT1 蛋白)).
hOGG1 mRNA is downregulated in non-small cell lung cancer tissues. Methylated +322-327 CpG site in the hOGG1 5'-UTR is associated with reduced expression of hOGG1 by decreasing the recruitment of Sp1 to the 5'-UTR of hOGG1 in A549 cells.
uPA (显示 PRAP1 蛋白) protection is independent of its catalytic activity, as the amino terminal fragment of uPA (显示 PRAP1 蛋白) showed similar protection. A key enzyme for repairing oxidative DNA damage is the p53 (显示 TP53 蛋白) target hOGG1. We found a significant increase of hOGG1 after pretreatment of HACM with uPA (显示 PRAP1 蛋白). Knockdown of hOGG1 completely abrogated the protective effect of uPA (显示 PRAP1 蛋白)
HOGG1 Ser326Cys, APE1 (显示 APEX1 蛋白) Asp148Glu and XRCC1 (显示 XRCC1 蛋白) Arg399Gln polymorphisms are correlated with the risk and clinicopathological features of PACG.
The Gene expression levels of OGG1 was robustly elevated in oligodendrocytes laser captured from BA10 and amygdala white matter of Major Depressive Disorder.
The findings showed that hOGG1-Ser326Cys Cys (显示 DNAJC5 蛋白) allele is statistically important and relevant with respect to the development of oral squamous cancer.
Overexpressed beta-OGG1 has the same role as alpha-OGG1 in protecting bronchial epithelial cells from apoptosis and mitochondrial dysfunction. Additionally, knocking down OGG1 enhanced oxidative damage-induced apoptosis and mitochondrial dysfunction. The antiapoptotic function of beta-OGG1 involved the JNK (显示 MAPK8 蛋白) signaling pathway.
The rs2304277 variant in the OGG1 glycosidase gene associated to a significant OGG1 transcriptional down regulation independently of the BRCA mutational status and this variant may exert a synergistic effect together with BRCA1 or BRCA2 (显示 BRCA2 蛋白) mutations in ovarian cancer
Data show that the total liver tumors was significantly higher in the N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (显示 BAG3 蛋白) (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH (显示 DST 蛋白))-administered oxoguanine glycosylase 1 (Ogg1) knockout (-)(/)(-) males and females.
8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced (显示 SQSTM1 蛋白) DNA demethylation.
OGG1 plays a role in an LSD1 (显示 KDM1A 蛋白)-dependent pathway of LPS (显示 TLR4 蛋白)-induced macrophage activation in mice.
These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury.
These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.
DNA repair protein (显示 ATRIP 蛋白) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (显示 NFKB1 蛋白) and functions in epigenetic regulation of gene expression.
OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation.
OGG1 acts as a STAT1 (显示 STAT1 蛋白) coactivator and has transcriptional activity in the presence of endotoxin
Ogg1 and Mutyh (显示 MUTYH 蛋白) regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f