Use your antibodies-online credentials, if available.
OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (显示 ARFRP1 蛋白) in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
Results provide evidence that OGG1 rs1052133 is significantly associated with Wilms tumor susceptibility.
TNF-alpha (显示 TNF 蛋白) - Reactive Oxygen Species -driven enrichment of OGG1 at gene regulatory regions in the chromatinized DNA, which is a prerequisite to modulation of gene expression for prompt cellular responses to oxidant stress.
OGG1 S326C polymorphism increases probability of AML (显示 RUNX1 蛋白) relapse and may be useful as a prognostic factor for AML (显示 RUNX1 蛋白) relapse risk.
This study identifies patient's carrying the OGG1 Ser326Cys CC genotype are at greater risk for HIV associated low birth weight, and delivering prematurely.
Of 39 subfertile men, 74.4% (29/39) had the hOGG1 Cys/Cys (显示 DNAJC5 蛋白) genotype. Patients in groups 1 and 2 with hOGG1 Cys/Cys (显示 DNAJC5 蛋白) genotype had significantly higher 8-OHdG content in sperm DNA, lower mitochondrial copy number in spermatozoa and lower TAC (显示 IL2RA 蛋白) in seminal plasma than those with Ser/Ser (显示 SIGLEC1 蛋白) or Ser (显示 SIGLEC1 蛋白)/Cys (显示 DNAJC5 蛋白) genotype.
CDK4/6 (显示 CDK4 蛋白) inhibitors also lead to accumulation of DNA damage by repressing PARP1 (显示 PARP1 蛋白) in oxidatively stressed cells. Thus, CDK4/6 (显示 CDK4 蛋白) inhibitors sensitize G1-arrested cells to anticancer drugs, since these cells require PARP1 (显示 PARP1 蛋白)-OGG1 functional interaction for cell survival
OGG1-2a, a critical enzyme for 8-OH-dG repair, is a direct target of miR (显示 MLXIP 蛋白)-200a and its expression levels significantly decrease in aged keratinocytes.
The level of OGG1 expression was significantly reduced in bipolar patients compared to healthy individuals, whereas the two groups exhibited similar levels of NEIL1 (显示 NEIL1 蛋白) expression.
Results identified a significant relationship between SNP rs13181 of OGG1 and an increased risk of endometrial cancer development.
The OGG1 gene presents downregulation in the more advanced stages of colorectal cancer
These observations imply that pre-excision step(s) during OGG1 initiated base excision repair evoked by reactive oxygen species facilitates NF-kappaB (显示 NFKB1 蛋白) DNA occupancy and gene expression.
Me-Pa toxicity alters Ogg1 and Nrf2 (显示 NFE2L2 蛋白) promoter methylation.
we show for the first time that OGG1 plays a distinct role in regulation of blood hepatic glucose production.
Data show that the total liver tumors was significantly higher in the N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (显示 BAG3 蛋白) (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH (显示 DST 蛋白))-administered oxoguanine glycosylase 1 (Ogg1) knockout (-)(/)(-) males and females.
8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced (显示 SQSTM1 蛋白) DNA demethylation.
OGG1 plays a role in an LSD1 (显示 KDM1A 蛋白)-dependent pathway of LPS (显示 TLR4 蛋白)-induced macrophage activation in mice.
These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury.
These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.
DNA repair protein (显示 ATRIP 蛋白) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (显示 NFKB1 蛋白) and functions in epigenetic regulation of gene expression.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f