DKC1 抗体
(Dyskeratosis Congenita 1, Dyskerin (DKC1))
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins. The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins. The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction. Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene. Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases. Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
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78 results
DKC1
适用: 人, 兔, Cow, 犬, 绵羊, 斑马鱼, 猴, 豚鼠, 马, Hamster, Pig
WB
宿主: 兔
Polyclonal
unconjugated
1 image
DKC1
适用: 人, 小鼠, 大鼠
WB, IHC, IF, ELISA
宿主: 兔
Polyclonal
unconjugated
1 image
DKC1
适用: 人
WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
DKC1
适用: 人
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 750
Latest Publications for our DKC1 抗体
: "snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis." in: Translational oncology, Vol. 6, Issue 4, pp. 447-57, (2013) (PubMed).: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "Molecular markers implicating early malignant events in cervical carcinogenesis." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 8, pp. 2003-12, (2010) (PubMed).
: "DKC1 overexpression associated with prostate cancer progression." in: British journal of cancer, Vol. 101, Issue 8, pp. 1410-6, (2009) (PubMed).
: "Relationship between dyskerin expression and telomerase activity in human breast cancer." in: Cellular oncology : the official journal of the International Society for Cellular Oncology, Vol. 30, Issue 6, pp. 483-90, (2008) (PubMed).
: "Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita." in: Science (New York, N.Y.), Vol. 312, Issue 5775, pp. 902-6, (2006) (PubMed).
Aliases for DKC1 抗体
dyskerin pseudouridine synthase 1 (DKC1) 抗体microRNA 664b (MIR664B) 抗体
dyskeratosis congenita 1, dyskerin (dkc1) 抗体
dyskeratosis congenita 1, dyskerin L homeolog (dkc1.L) 抗体
dyskeratosis congenita 1, dyskerin (Dkc1) 抗体
dyskerin pseudouridine synthase 1 (Dkc1) 抗体
homologue of NAP57 (NAP57) 抗体
AtCBF5 抗体
AtNAP57 抗体
BC068171 抗体
CBF5 抗体
cbf5 抗体
DKC 抗体
dkc 抗体
DKC1 抗体
DKCX 抗体
dyskerin 抗体
fv62a07 抗体
homologue of NAP57 抗体
NAP57 抗体
nap57 抗体
Nap57 抗体
NOLA4 抗体
nola4 抗体
wu:fa28f10 抗体
wu:fc87a02 抗体
wu:fi24a05 抗体
wu:fv62a07 抗体
XAP101 抗体
xap101 抗体
zgc:110395 抗体
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