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DKC1 抗体 (AA 171-220)

The 兔 多克隆 anti-DKC1 antibody is suitable to detect DKC1 in samples from 人, 小鼠 和 大鼠. It has been validated for WB, IHC, IF 和 ELISA.
产品编号 ABIN1533529
发货至: 中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for DKC1 抗体 (AA 171-220) (ABIN1533529)

抗原

See all DKC1 抗体
DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

适用

  • 99
  • 63
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  • 1
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人, 小鼠, 大鼠

宿主

  • 99
  • 3
  • 1
兔

克隆类型

  • 72
  • 31
多克隆

标记

  • 38
  • 8
  • 5
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  • 4
  • 4
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  • 4
  • 2
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This DKC1 antibody is un-conjugated

应用范围

  • 83
  • 50
  • 41
  • 31
  • 29
  • 13
  • 13
  • 13
  • 7
  • 5
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA
  • 抗原表位

    • 15
    • 13
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
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    • 1
    AA 171-220

    原理

    Dyskerin Antibody

    特异性

    Dyskerin Polyclonal Antibody detects endogenous levels of Dyskerin protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    纯度

    > 95 %

    免疫原

    The antiserum was produced against synthesized peptide derived from human Dyskerin. AA range:171-220

    亚型

    IgG
  • 应用备注

    WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C/1 year

    有效期

    12 months
  • 抗原

    DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))

    别名

    Dyskerin

    背景

    Synonyms: DKC1, NOLA4, H/ACA ribonucleoprotein complex subunit 4, CBF5 homolog, Dyskerin, Nopp140-associated protein of 57 kDa, Nucleolar protein NAP57, Nucleolar protein family A member 4, snoRNP protein DKC1

    Background: dyskerin pseudouridine synthase 1(DKC1) Homo sapiens This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

    Gene Name: DKC1

    Protein Name: H/ACA ribonucleoprotein complex subunit 4

    分子量

    57 kDa

    基因ID

    1736

    OMIM

    300126

    UniProt

    O60832

    途径

    Telomere Maintenance
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