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Claspin 产品

(Claspin (CLSPN))

Categories

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

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Featured Claspin Categories

Claspin 抗体

High quality antibodies with extensive validation data.

Recommended Claspin 抗体

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Reactivity Human, Mouse, Rat
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Cat. No. ABIN6260859
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Cat. No. ABIN7266402
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Recommended Claspin ELISA试剂盒

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Reactivity Mouse
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Cat. No. ABIN1126689
Quantity 96 tests
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Reactivity Human
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Cat. No. ABIN1126688
Quantity 96 tests
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Recommended Claspin 蛋白

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Cat. No. ABIN3091815
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Cat. No. ABIN3136084
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Latest Publications for our Claspin Products

Speroni, Federico, Mansilla, Soria, Gottifredi: "Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 19, pp. 7344-9, (2012) (PubMed).

Benevolo, Musio, Vocaturo, Donà, Rollo, Terrenato, Carosi, Pescarmona, Vocaturo, Mottolese: "Claspin as a biomarker of human papillomavirus-related high grade lesions of uterine cervix." in: Journal of translational medicine, Vol. 10, pp. 132, (2012) (PubMed).

Guervilly, Renaud, Takata, Rosselli: "USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation." in: Human molecular genetics, Vol. 20, Issue 11, pp. 2171-81, (2011) (PubMed).

Despras, Daboussi, Hyrien, Marheineke, Kannouche: "ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells." in: Human molecular genetics, Vol. 19, Issue 9, pp. 1690-701, (2010) (PubMed).

Castriconi, Daga, Dondero, Zona, Poliani, Melotti, Griffero, Marubbi, Spaziante, Bellora, Moretta, Moretta, Corte, Bottino: "NK cells recognize and kill human glioblastoma cells with stem cell-like properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3530-9, (2009) (PubMed).

Gao, Inuzuka, Korenjak, Tseng, Wu, Wan, Kirschner, Dyson, Wei: "Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways." in: Molecular biology of the cell, Vol. 20, Issue 14, pp. 3305-16, (2009) (PubMed).

Guervilly, Macé-Aimé, Rosselli: "Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia." in: Human molecular genetics, Vol. 17, Issue 5, pp. 679-89, (2008) (PubMed).

Yang, Shiotani, Classon, Zou: "Chk1 and Claspin potentiate PCNA ubiquitination." in: Genes & development, Vol. 22, Issue 9, pp. 1147-52, (2008) (PubMed).

Li, Elder, Qin, Park, Liang, Zhao: "Phosphatase type 2A-dependent and -independent pathways for ATR phosphorylation of Chk1." in: The Journal of biological chemistry, Vol. 282, Issue 10, pp. 7287-98, (2007) (PubMed).

Yoshizawa-Sugata, Masai: "Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint." in: The Journal of biological chemistry, Vol. 282, Issue 4, pp. 2729-40, (2007) (PubMed).

Synonyms and alternative names related to Claspin

claspin (Clspn), claspin (CLSPN), claspin (clspn), claspin S homeolog (clspn.S), B130025E01, C85083, CLSPN, E130314M08Rik, xClaspin

Protein level used designations for Claspin

  • claspin homolog (Xenopus laevis)
  • claspin
  • claspin homolog
  • hClaspin
  • xClaspin
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