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CKAP5 产品

(Cytoskeleton Associated Protein 5 (CKAP5))

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This gene encodes a cytoskeleton-associated protein which belongs to the TOG/XMAP215 family. The N-terminal half of this protein contains a microtubule-binding domain and the C-terminal half contains a KXGS motif for binding tubulin dimers. This protein has two distinct roles in spindle formation\; it protects kinetochore microtubules from depolymerization and plays an essential role in centrosomal microtubule assembly. This protein may be necessary for the proper interaction of microtubules with the cell cortex for directional cell movement. It also plays a role in translation of the myelin basic protein (MBP) mRNA by interacting with heterogeneous nuclear ribonucleoprotein (hnRNP) A2, which associates with MBP. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

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Featured CKAP5 Categories

CKAP5 抗体

High quality antibodies with extensive validation data.

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Latest Publications for our CKAP5 Products

Milunovic-Jevtic, Jevtic, Levy, Gatlin: "In vivo mitotic spindle scaling can be modulated by changing the levels of a single protein: the microtubule polymerase XMAP215." in: Molecular biology of the cell, Vol. 29, Issue 11, pp. 1311-1317, (2018) (PubMed).

Kourtidis, Anastasiadis: "PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications." in: Cell cycle (Georgetown, Tex.), Vol. 15, Issue 4, pp. 498-505, (2016) (PubMed).

Dionne, Sanchez, Compton: "ch-TOGp is required for microtubule aster formation in a mammalian mitotic extract." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 12346-52, (2000) (PubMed).

Synonyms and alternative names related to CKAP5

cytoskeleton associated protein 5 (ckap5), cytoskeleton associated protein 5 S homeolog (ckap5.S), cytoskeleton associated protein 5 (CKAP5), cytoskeleton-associated protein 5 (LOC100548902), cytoskeleton associated protein 5 (Ckap5), 3110043H24Rik, 4930432B04Rik, ch-TOG, CHTOG, ckap5, CKAP5, ckap5b, D730027C18Rik, im:7143385, mKIAA0097, msps, MSPS, T25636, tog, TOG, togp, TOGp, wu:fb14c01, wu:fb59e03, wu:fi33f02, xmap215, zgc:123012

Protein level used designations for CKAP5

  • cytoskeleton associated protein 5
  • microtubule associated protein XMAP215
  • cytoskeleton-associated protein 5
  • microtubule-associated protein 215
  • colonic and hepatic tumor over-expressed protein
  • Cytoskeleton-associated protein 5
  • cytoskeleton-associated protein 5-like
  • colonic and hepatic tumor over-expressed gene protein
  • colonic and hepatic tumor overexpressed gene protein
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