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Study presents the first demonstration that GBP2 inhibits mitochondrial fission and cell metastasis in breast cancer cells both in vitro and in vivo.
Low GBP2 expression is associated with metastasis in breast cancer.
GBP1 (显示 GBP1 蛋白)/2 are critical effectors of antichlamydial interferon (IFN)gamma (显示 IFNA 蛋白)-mediated pathogen clearance via rerouting of bacterial inclusions in macrophages for lysosomal degradation.
Downregulation of MIR (显示 MLXIP 蛋白)-433 is associated with myeloproliferative neoplasms.
The in vivo localization of GBP-2 at cellular membranes is regulated by isoprenylation and dimerization.
hGBP-1, hGBP-2 showed dimerization-related GTPase (显示 RACGAP1 蛋白) activity for GMP (显示 NT5C2 蛋白) formation.
Guanylate-binding protein 2 mRNA in peripheral blood leukocytes may have a role in acute cellular rejection after liver transplantation
Sky1p utilizes the same docking groove to bind yeast SR-like protein (显示 PNN 蛋白) Gbp2p and phosphorylates all three serines present in a contiguous RS dipeptide stretch
GBP-2 is regulated by p53 (显示 TP53 蛋白) and may have a role in esophageal squamous cell carcinomas
GBP2 can effectively regulate beta-glucan-induced maturation of DCs, thus suppressing the proliferation of T cells.
GBP1 (显示 GBP1 蛋白) GBP2 enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 (显示 AIM2 蛋白) during infection with F. novicida.
This study begins to define the properties of mGBP-2 responsible for inhibiting cell spreading.
Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.
the inducible multimerization of mGBP2 is dependent on a functional GTPase (显示 RACGAP1 蛋白) domain.
IRGM (显示 IRGM 蛋白) proteins indirectly modulate the localization of GBP2 through a distinct mechanism from that through which they regulate IRG protein localization
mGBP-2 inhibits TNF-alpha (显示 TNF 蛋白) activation of endogenous Rac1 and constitutively activate Rac (显示 AKT1 蛋白) can restore NF-kappaB (显示 NFKB1 蛋白) transcription in the presence of mGBP-2. This is a novel mechanism by which IFNs can inhibit the cytokine induction of MMP-9 (显示 MMP9 蛋白) expression.
Both IFN-gamma (显示 IFNG 蛋白) and mGBP-2 also inhibit cell spreading initiated by platelet-derived growth factor treatment, which is also accompanied by inhibition of Rac (显示 AKT1 蛋白) activation by mGBP-2.
inhibits replication of both vesicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV); a wild type GTP binding (显示 RND2 蛋白) motif was not required for VSV inhibition but was required for inhibition of EMCV
cDNA sequences were cloned and the genomic structure of porcine GBP1 (显示 GBP1 蛋白) (poGBP1) and GBP2 (poGBP2), was analyzed.
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP.
GTP-binding protein 2
, guanine nucleotide-binding protein 2
, interferon-induced guanylate-binding protein 2
, guanylate nucleotide binding protein 2
, isoprenylated 67 kDa protein