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Data revealed that MLF interacts with CSN3 in vivo and that the PCI (显示 SERPINA5 蛋白) domain of the dCSN3 protein is sufficient for this to occur, possibly functioning as a structural scaffold for assembly of the COP9 (显示 COPS8 蛋白) signalosome complex.
This is the first study toward understanding the role of the CSN3 (显示 CSN3 蛋白) in skeletal muscle differentiation and proliferation. Our results show that knockdown of CSN3 (显示 CSN3 蛋白) in C2C12 cells leads to impaired differentiation, proliferation and cell cycle regulation of myoblasts.
CSN3 (显示 CSN3 蛋白) and CSN5 (显示 COPS5 蛋白) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (显示 CCNB1 蛋白) and Securin (显示 PTTG1 蛋白) via APC (显示 APC 蛋白)/C.
Cops3 encodes the third subunit of the COP9 (显示 COPS8 蛋白) signalosome, which controls a wide vasriety of molecules of different functions.
CSN3 functions in a distinct protein complex that is required for proper auxin signaling.
Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.
this study demonstrates Csn3 (显示 CSN3 蛋白) as an oncogene (显示 RAB1A 蛋白) that regulates the tumorigenesis process in hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) cells.
of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila COP9 signalosome homolog 3
, COP9 signalosome complex subunit 3
, COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
, COP9 constitutive photomorphogenic homolog subunit 3
, COP9 signalosome complex subunit 3-like
, COP9 (constitutive photomorphogenic), subunit 3
, COP9 complex S3
, JAB1-containing signalosome subunit 3
, signalosome subunit 3
, COP9 complex subunit 3
, COP9 (constitutive photomorphogenic) homolog, subunit 3