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Data revealed that MLF interacts with CSN3 in vivo and that the PCI domain of the dCSN3 protein is sufficient for this to occur, possibly functioning as a structural scaffold for assembly of the COP9 signalosome complex.
This is the first study toward understanding the role of the CSN3 in skeletal muscle differentiation and proliferation. Our results show that knockdown of CSN3 in C2C12 cells leads to impaired differentiation, proliferation and cell cycle regulation of myoblasts.
CSN3 and CSN5 are involved in oocyte meiosis by regulating degradation of Cyclin B1 and Securin via APC/C.
Cops3 encodes the third subunit of the COP9 signalosome, which controls a wide vasriety of molecules of different functions.
CSN3 functions in a distinct protein complex that is required for proper auxin signaling.
Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
COPS3 may be a new potential target of clear cell renal cell carcinoma.
Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.
this study demonstrates Csn3 as an oncogene that regulates the tumorigenesis process in hepatocellular carcinoma (HCC) cells.
of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila COP9 signalosome homolog 3
, COP9 signalosome complex subunit 3
, COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
, COP9 constitutive photomorphogenic homolog subunit 3
, COP9 signalosome complex subunit 3-like
, COP9 (constitutive photomorphogenic), subunit 3
, COP9 complex S3
, JAB1-containing signalosome subunit 3
, signalosome subunit 3
, COP9 complex subunit 3
, COP9 (constitutive photomorphogenic) homolog, subunit 3