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Here the authors identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent entry of enterovirus D68.
ICAM5 V301I and rs281439 variants may contribute to the susceptibility of breast cancer. [Meta-analysis]
A specific microenvironment facilitating ARF6 (显示 ARF6 蛋白)-mediated mobilization of TLN that contributes to promotion of dendritic spine development.
study does not confirm association between ICAM 5 V3001 polymorphism and breast cancer risk
ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent.
Data show that estradiol or bisphenol A decreased expression of luteinizing hormone beta (Lhb (显示 LHB 蛋白)), follicle stimulating hormone beta (Fshb (显示 FSHB 蛋白)), and intracellular adhesion molecule (显示 NCAM1 蛋白)-5 (Icam5) in females but only decreased expression of Icam5 in males.
This study revealed a similar expression of ICAM-5 in dendritic elements at P14 (显示 PCOLCE 蛋白) and P28 (显示 GSTO1 蛋白); however, an increased prevalence of ICAM-5 was noted in dendritic protrusions at P28 (显示 GSTO1 蛋白) in the MMP-9 (显示 MMP9 蛋白) null animals
Results suggest that the interaction between ICAM-5 and beta1 integrins is important in formation of functional synapses.
MMPs and soluble ICAM-5 increase neuronal excitability
the extracellular matrix molecule VN and its neuronal receptor TLCN play a pivotal role in the phosphorylation of ezrin/radixin/moesin (显示 MSN 蛋白) proteins and the formation of phagocytic cup-like structures on neuronal dendrites
analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4 (显示 TLR4 蛋白)), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3 (显示 ICAM3 蛋白))-grabbing nonintegrin (DC-SIGN (显示 CD209 蛋白)), and beta2 integrins
A novel serine-rich motif in the intercellular adhesion molecule 3 (显示 ICAM3 蛋白) is critical for its ezrin/radixin/moesin (显示 MSN 蛋白)-directed subcellular targeting
Collectively, PS1 (显示 PSEN1 蛋白) deficiency affects in a gamma-secretase-independent fashion the turnover of telencephalin through autophagic vacuoles, most likely by an impaired capability to fuse with lysosomes.
Study defines a physiological mechanism for the proteolytic processing of ICAM-5 by MMP-2 (显示 MMP2 蛋白) and MMP-9 (显示 MMP9 蛋白) and the importance of the its cleavage on regulation of dendritic spine development.
Our results suggest that ICAM-5 plays a critical role in modulating chemokine (显示 CCL1 蛋白) production in the CNS.
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
, intercellular adhesion molecule 5
, intercellular adhesion molecule 3
, LOW QUALITY PROTEIN: intercellular adhesion molecule 5
, intercellular adhesion molecule 5, telencephalin
, intercellular adhesion molecule 5 L homeolog