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CDK5 蛋白

(Cyclin-Dependent Kinase 5 (CDK5))
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

17 results :

custom-made CDK5 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7563341
 
custom-made CDK5 宿主: 人 宿主: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
产品编号 ABIN7553063
 
CDK5 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Pubmed 1 reference
产品编号 ABIN1348956
 
CDK5 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
产品编号 ABIN5855017
 
CDK5 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 94 % as determined by reducing SDS-PAGE.
产品编号 ABIN7195315
 
CDK5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant SDS, WB, ELISA
产品编号 ABIN7576065
 
CDK5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant SDS, WB, ELISA
产品编号 ABIN7576066
 
CDK5 宿主: 大鼠 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS, WB, Imm, PC
产品编号 ABIN7411225
 
CDK5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 95 % SDS, WB, Imm, PC
产品编号 ABIN7391882
 
CDK5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS, WB, Imm, PC
产品编号 ABIN7421041
 
CDK5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 85 % pure SDS
产品编号 ABIN2128476
 
custom-made CDK5 宿主: 小鼠 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
产品编号 ABIN3134259
 
custom-made CDK5 宿主: 人 宿主: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA
产品编号 ABIN3090892
 
CDK5 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 90 % SDS
产品编号 ABIN5709263
 
CDK5 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2713865
 
CDK5 宿主: 大鼠 宿主: 大肠杆菌(E. Coli) Recombinant SDS, WB
产品编号 ABIN6122177
 
CDK5 宿主: 非洲爪蟾 宿主: 酵母菌 Recombinant > 90 % ELISA
产品编号 ABIN1477469
 
  • 类型 Protein
    • Protein
  • 应用范围
    • SDS-PAGE (SDS)
    • Western Blotting (WB)
    • ELISA
    • Immunogen (Imm)
    • Positive Control (PC)
    • Affinity Purification (AP)
    • Antibody Array (AA)
    • Antibody Production (AbP)
    • Standard (STD)
  • 适用
    • Human
    • Mouse
    • Rat
    • Xenopus laevis
  • 论文引用
  • 图像
  • Carrier free only
  • 抗体来源
    • Escherichia coli (E. coli)
    • HEK-293 Cells
    • Baculovirus infected Insect Cells
    • Cell-free protein synthesis (CFPS)
    • Wheat germ
    • Yeast
  • 抗原表位
    • AA 1-292
    • AA 92-273
    • full length
  • 标记
    • His tag
    • GST tag
    • Strep Tag
    • 非结合性
    • His tag,SUMO Tag
    • His-SUMO Tag
    • Myc-DYKDDDDK Tag
  • 蛋白类型
    • Recombinant
  • Format
    • Liquid
    • Lyophilized
  • Grade
    • custom-made
  • Supplier
    • antibodies-online
    • Abbexa
    • CUSABIO
    • OriGene
    • Signalway

Latest Publications for our CDK5 蛋白

Seo, Kim, Bae, Soh, Lee: "Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15601-10, (2008) (PubMed).

Aliases for CDK5 蛋白

cyclin dependent kinase 5 (CDK5) 蛋白
cyclin-dependent kinase 5 (Cdk5) 蛋白
Cyclin-dependent kinase 5 (Cdk5) 蛋白
cyclin-dependent kinase 5 (cdk5) 蛋白
cyclin-dependent kinase 5 L homeolog (cdk5.L) 蛋白
cyclin dependent kinase 5 (Cdk5) 蛋白
Cyclin-dependent-like kinase 5 (cdk-5) 蛋白
AW048668 蛋白
CDK5 蛋白
cdk5 蛋白
CG8203 蛋白
Crk6 蛋白
DmCdk5 蛋白
Dmel\\CG8203 蛋白
PSSALRE 蛋白
zgc:101604 蛋白
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