CD59 抗体
(CD59)
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].
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Latest Publications for our CD59 抗体
: "Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT." in: Molecular biotechnology, (2018) (PubMed).: "A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174074, (2017) (PubMed).
: "The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events." in: Cell metabolism, Vol. 19, Issue 5, pp. 883-90, (2014) (PubMed).
: "Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease." in: Journal of internal medicine, Vol. 276, Issue 5, pp. 470-85, (2014) (PubMed).
: "Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells." in: Chembiochem : a European journal of chemical biology, Vol. 15, Issue 10, pp. 1393-8, (2014) (PubMed).
: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" in: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).
: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).
: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).
: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, (2007) (PubMed).
: "Complement susceptibility in glutamine deprived breast cancer cells." in: Cell division, Vol. 2, pp. 20, (2007) (PubMed).
Aliases for CD59 抗体
CD59 molecule (CD59 blood group) (CD59) 抗体CD59 molecule (Cd59) 抗体
CD59 molecule (CD59) 抗体
1F5 抗体
16.3A5 抗体
Cd59a 抗体
Cd59b 抗体
EJ16 抗体
EJ30 抗体
EL32 抗体
G344 抗体
HRF-20 抗体
HRF20 抗体
MAC-IP 抗体
MACIF 抗体
MACIP 抗体
MEM43 抗体
MIC11 抗体
MIN1 抗体
MIN2 抗体
MIN3 抗体
MIRL 抗体
MSK21 抗体
p18-20 抗体
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