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CD59 产品

(CD59)

Categories

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

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Featured CD59 Categories

CD59 抗体

High quality antibodies with extensive validation data.

CD59 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CD59 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CD59 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS, WB, IHC, ELISA, ICC
Validations
  • (2)
  • (8)
Cat. No. ABIN1098134
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application FACS, WB, IF, IHC (p)
Validations
  • (5)
Cat. No. ABIN6242239
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application FACS, IP, IHC (p)
Validations
  • (4)
  • (4)
Cat. No. ABIN94199
Quantity 0.1 mg
Datasheet Datasheet

Recommended CD59 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6960667
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965598
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965599
Quantity 96 tests
Datasheet Datasheet

Recommended CD59 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7274197
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7319910
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122212
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CD59 Products

Liu, Liu, Yuan, Qing, Li, Xu, Zhu, Zhao, Jia, Pan, Guo, Zhang, Cheng, Wang, Zhao, Wei: "Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT." in: Molecular biotechnology, (2018) (PubMed).

Yuan, Li, Baines, Gavriilaki, Ye, Wen, Braunstein, Biesecker, Cheng, Dong, Brodsky: "A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model." in: PLoS ONE, Vol. 12, Issue 4, pp. e0174074, (2017) (PubMed).

Budding, van de Graaf, Kardol-Hoefnagel, Kwakkel-van Erp, Luijk, Oudijk, van Kessel, Grutters, Hack, Otten: "Soluble CD59 is a Novel Biomarker for the Prediction of Obstructive Chronic Lung Allograft Dysfunction After Lung Transplantation." in: Scientific reports, Vol. 6, pp. 26274, (2016) (PubMed).

Krus, King, Nagaraj, Gandasi, Sjölander, Buda, Garcia-Vaz, Gomez, Ottosson-Laakso, Storm, Fex, Vikman, Zhang, Barg, Blom, Renström: "The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events." in: Cell metabolism, Vol. 19, Issue 5, pp. 883-90, (2014) (PubMed).

Miyaji, Paul, Shahrizaila, Umapathi, Yuki: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" in: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).

Su, Wang, Gao, Liu, Pan, Hu, Beyer, Shi, Zhou, Zhang, Serra, Wüthrich, Mei: "Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease." in: Journal of internal medicine, Vol. 276, Issue 5, pp. 470-85, (2014) (PubMed).

Sheridan, Hudon, Hank, Sondel, Kiessling: "Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells." in: Chembiochem : a European journal of chemical biology, Vol. 15, Issue 10, pp. 1393-8, (2014) (PubMed).

Alegretti, Mucenic, Merzoni, Faulhaber, Silla, Xavier: "Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients." in: Cellular immunology, Vol. 265, Issue 2, pp. 127-32, (2010) (PubMed).

Ma, Chang, Qin, Sun, Huang, He: "Decreased expression of complement regulatory proteins, CD55 and CD59, on peripheral blood leucocytes in patients with type 2 diabetes and macrovascular diseases." in: Chinese medical journal, Vol. 122, Issue 18, pp. 2123-8, (2009) (PubMed).

Drbal, Moertelmaier, Holzhauser, Muhammad, Fuertbauer, Howorka, Hinterberger, Stockinger, Schütz: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, (2007) (PubMed).

Synonyms and alternative names related to CD59

CD59 molecule (CD59 blood group) (CD59), CD59 molecule (Cd59), CD59 molecule (CD59), 1F5, 16.3A5, Cd59a, Cd59b, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MACIP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20

Protein level used designations for CD59

  • 1F5 antigen
  • 20 kDa homologous restriction factor
  • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)
  • CD59 glycoprotein
  • Ly-6-like protein
  • MEM43 antigen
  • T cell-activating protein
  • human leukocyte antigen MIC11
  • lymphocytic antigen CD59/MEM43
  • membrane attack complex (MAC) inhibition factor
  • membrane attack complex inhibition factor
  • membrane inhibitor of reactive lysis
  • protectin
  • surface anitgen recognized by monoclonal antibody 16.3A5
  • CD59 antigen
  • CD59b moleucle, complement regulatory protein
  • Cb59b molecule
  • MAC-inhibitory protein
  • MAC-IP
  • MACIF
  • CD59 homolog
  • CD59 molecule, complement regulatory protein
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