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抗Human SH2B2 抗体:
抗Mouse (Murine) SH2B2 抗体:
抗Rat (Rattus) SH2B2 抗体:
Studies indicate that insulin receptor (IR (显示 INSR 抗体)) and IGF Type 1 Receptor (IGFR) have been identified as important partners of Grb10 (显示 GRB10 抗体)/14 and SH2B1 (显示 SH2B1 抗体)/B2 adaptors.
We present here a novel stimulatory mechanism of Vav3 (显示 VAV3 抗体) in which APS directly relieves the autoinhibitory CH domain and furthermore enhances its tyrosine phosphorylation by Lck (显示 LCK 抗体).
N-terminal residues distal to the phosphotyrosine directly contact residues of the four-helix bundle of the TKB domain of the adapter protein (显示 TOLLIP 抗体) APS
Deletion of liver SH2B1 (显示 SH2B1 抗体) in SH2B2 null mice attenuated very low-density lipoprotein (VLDL) secretion.
APS facilitates c-Cbl (显示 CBL 抗体) tyrosine phosphorylation and GLUT4 (显示 SLC2A4 抗体) translocation in response to insulin (显示 INS 抗体) in 3T3-L1 adipocytes
Data show that the adapter protein APS preferentially associates with phosphorylated Tyr-568 and Tyr-936 of the receptor for stem-cell factor (c-Kit).
Lnk (显示 SH2B3 抗体), SH2-B (显示 SH2B1 抗体), and APS have roles in mast cell development, growth, and functions
APS might have a novel regulatory role in actin reorganization and control of B-1 cell compartment size.
Knockdown of the mouse APS gene abolished the insulin (显示 INS 抗体)-stimulated phosphorylation of c-Cbl (显示 CBL 抗体).
APS appears to play novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells
These results identify Enigma as a novel APS-binding protein and suggest that the APS/Enigma complex plays a critical role in actin cytoskeleton organisation.
SH2-B (显示 SH2B1 抗体), but not APS, is a key positive regulator of energy and glucose metabolism in mice
APS enhanced ligand-dependent multi-ubiquitination of the insulin receptor (IR (显示 INSR 抗体)) in CHO (显示 COL11A1 抗体) cells.
Association between variations in the SH2B2 gene and growth traits in Chinese cattle.
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway.
SH2 and PH domain-containing adapter protein APS
, SH2B adapter protein 2
, adapter protein with pleckstrin homology and Src homology 2 domains
, adaptor protein with pleckstrin homology and src homology 2 domains
, insulin receptor substrate 5
, SH2B adaptor protein 2
, SH2B adapter protein 2-like