BRE 产品
(Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
Categories
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity).
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Featured BRE Categories
Recommended BRE 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7265912
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC, IP
Validations
- (4)
Cat. No.
ABIN2856093
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7145788
Quantity
100 μg
Datasheet
Datasheet
Recommended BRE ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6225296
Quantity
96 tests
Datasheet
Datasheet
Recommended BRE 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1346865
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3090443
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136588
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our BRE Products
: "Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells." in: Apoptosis : an international journal on programmed cell death, Vol. 19, Issue 5, pp. 829-40, (2014) (PubMed).: "BRE is an antiapoptotic protein in vivo and overexpressed in human hepatocellular carcinoma." in: Oncogene, Vol. 27, Issue 9, pp. 1208-17, (2008) (PubMed).
: "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52106-16, (2004) (PubMed).
: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).
: "Expression of human BRE in multiple isoforms." in: Biochemical and biophysical research communications, Vol. 288, Issue 3, pp. 535-45, (2001) (PubMed).
: "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." in: Biochemical and biophysical research communications, Vol. 206, Issue 2, pp. 764-74, (1995) (PubMed).
Synonyms and alternative names related to BRE
BRISC and BRCA1 A complex member 2 (babam2), BRISC and BRCA1 A complex member 2 (BABAM2), BRISC and BRCA1 A complex member 2 (Babam2), brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE), BRISC and BRCA1 A complex member 2 L homeolog (babam2.L), 6030405P19Rik, AI429776, B830038C02Rik, brcc4, BRCC4, brcc45, BRCC45, BRE, im:7141046, LOC100231620, zgc:110368Protein level used designations for BRE
- BRCA1-A complex subunit BRE
- BRCA1/BRCA2-containing complex subunit 45
- Brain and reproductive organ-expressed protein
- brain and reproductive organ-expressed (TNFRSF1A modulator)
- BRCA1-A complex subunit BRE-like
- BRCA1/BRCA2-containing complex, subunit 4
- brain and reproductive organ-expressed protein
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