This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011].
Hu, Zeng, Li, Meyer, Cui, Xu: "Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch." in: Journal of neurochemistry, (2015) (PubMed).