APH1B 抗体
(Anterior Pharynx Defective 1 Homolog B (Aph1b))
This gene encodes a multi-pass transmembrane protein that is a functional component of the gamma-secretase complex, which also contains presenilin and nicastrin. This protein represents a stabilizing cofactor for the presenilin holoprotein in the complex. The gamma-secretase complex catalyzes the cleavage of integral proteins such as notch receptors and beta-amyloid precursor protein. [provided by RefSeq, Sep 2011].
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Latest Publications for our APH1B 抗体
: "Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch." in: Journal of neurochemistry, (2015) (PubMed).Aliases for APH1B 抗体
aph-1 homolog B, gamma-secretase subunit (APH1B) 抗体aph-1 homolog B, gamma secretase subunit (Aph1b) 抗体
aph1 homolog B, gamma secretase subunit (Aph1b) 抗体
2310057K14Rik 抗体
APH-1B 抗体
APH-1B' 抗体
Aph1c 抗体
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