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- 抗原 See all NAC1 (NACC1) 抗体
- NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NAC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 纯化方法
- purified
- 免疫原
- Purified recombinant fragment of human NACC1 expressed in E. coli.
- 克隆位点
- 6H2
- 亚型
- IgG1
- Top Product
- Discover our top product NACC1 Primary Antibody
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anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (C-Term) antibody
NACC1 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (AA 324-358) antibodyNACC1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51582 unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) antibodyNACC1 适用: 人 IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (AA 291-340) antibodyNACC1 适用: 人, 大鼠, 小鼠, 犬, Cow, 马, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (C-Term) antibodyNACC1 适用: 人, 大鼠, 小鼠, 犬, Cow, 马, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) antibodyNACC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (AA 355-390), (C-Term) antibodyNACC1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB51581 unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) antibodyNACC1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (Internal Region) antibodyNACC1 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1) (Internal Region) antibodyVerified NACC1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- 4°C, -20°C for long term storage
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- 抗原
- NAC1 (NACC1) (Nucleus Accumbens Associated 1, BEN and BTB (POZ) Domain Containing (NACC1))
- 别名
- NACC1 (NACC1 产品)
- 别名
- BEND8 antibody, BTBD14B antibody, BTBD30 antibody, NAC-1 antibody, NAC1 antibody, NACC1 antibody, 2010001H03Rik antibody, 4930511N13Rik antibody, Btbd14b antibody, Nac1 antibody, Nac-1 antibody, nucleus accumbens associated 1 antibody, nucleus accumbens associated 1, BEN and BTB (POZ) domain containing antibody, NACC1 antibody, Nacc1 antibody
- 背景
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Description: NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .
Aliases: NAC1, BEND8, NAC-1, BTBD14B, FLJ37383, NACC1
- 分子量
- 58 kDa
- 基因ID
- 112939
- HGNC
- 112939
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