Caspase 8 抗体
(2 references)Quick Overview for Caspase 8 抗体 (ABIN969003)
抗原
See all Caspase 8 (CASP8) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- CASP8 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human CASP8 expressed in E. Coli.
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亚型
- IgG1
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anti-Caspase 8 (CASP8) (AA 411-482) antibody
CASP8 适用: 人, 小鼠, 大鼠, 猴, Pig, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 1-479) antibodyCASP8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 188-280) antibodyCASP8 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 385-479) antibodyCASP8 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 217-384) antibodyCASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 7-201) antibodyCASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 410-449), (N-Term) antibodyCASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 217-374) antibodyCASP8 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) antibodyCASP8 适用: 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 大鼠 Monoclonal 3B10 unconjugated
anti-Caspase 8 (CASP8) (pSer347) antibodyCASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Caspase-8 in cancer biology and therapy." in: Cancer letters, Vol. 281, Issue 2, pp. 128-33, (2009) (PubMed).
: "Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells." in: Cell research, Vol. 19, Issue 3, pp. 358-69, (2009) (PubMed).
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: "Caspase-8 in cancer biology and therapy." in: Cancer letters, Vol. 281, Issue 2, pp. 128-33, (2009) (PubMed).
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- Caspase 8 (CASP8)
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别名
- CASP8
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背景
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
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分子量
- 26 kDa
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基因ID
- 841
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UniProt
- Q14790
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途径
- Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
抗原
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