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Caspase 8 抗体 (AA 1-479)

Name: Caspase 8 抗体 (AA 1-479)
Brand: antibodies-online
SKU: ABIN6137970
Availability: OutOfStock

CASP8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

Immunohistochemistry of paraffin-embedded human colon carcinoma using Caspase-8 Rabbit pAb (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at dilution of 1:200 (40x lens).

IHC

IHC

IHC

Apoptosis related proteins were detected in EOMA cells after treated with DHTS and propranolol.

Western blot analysis of extracts of Jurkat cells, using Caspase-8 antibody (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded mouse kidney using Caspase-8 Rabbit pAb (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at dilution of 1:200 (40x lens).

IHC

Immunohistochemistry of paraffin-embedded rat kidney using Caspase-8 Rabbit pAb (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at dilution of 1:200 (40x lens).

IHC

Immunofluorescence analysis of HeLa cells using Caspase-8 Rabbit pAb (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at dilution of 1:200 (40x lens).

Immunofluorescence analysis of HepG2 cells using Caspase-8 Rabbit pAb (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at dilution of 1:200 (40x lens).

Western blot analysis of extracts of various cell lines, using Caspase-8 antibody (ABIN6131530, ABIN6137970, ABIN6137972 and ABIN6213676) at 1:1000 dilution.

12 images

(17 references)

产品编号 ABIN6137970

发货至: 中国

Datasheet as PDF

抗原 See all Caspase 8 (CASP8) 抗体

Caspase 8 (CASP8)
抗原表位
16

16

10

7

6

6

5

5

5

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

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1

1
AA 1-479
适用
135

70

63

23

16

16

10

1

1

1
人
宿主
129

24

5

2
兔
Compatible Secondaries
克隆类型
126

33
多克隆
标记
95

16

11

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2
This Caspase 8 antibody is un-conjugated
应用范围
141

50

43

38

27

26

25

20

19

18

8

4

4

4

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

序列

MDFSRNLYDI GEQLDSEDLA SLKFLSLDYI PQRKQEPIKD ALMLFQRLQE KRMLEESNLS FLKELLFRIN RLDLLITYLN TRKEEMEREL QTPGRAQISA YRVMLYQISE EVSRSELRSF KFLLQEEISK CKLDDDMNLL DIFIEMEKRV ILGEGKLDIL KRVCAQINKS LLKIINDYEE FSKGEELCGV MTISDSPREQ DSESQTLDKV YQMKSKPRGY CLIINNHNFA KAREKVPKLH SIRDRNGTHL DAGALTTTFE ELHFEIKPHD DCTVEQIYEI LKIYQLMDHS NMDCFICCIL SHGDKGIIYG TDGQEAPIYE LTSQFTGLKC PSLAGKPKVF FIQACQGDNY QKGIPVETDS EEQPYLEMDL SSPQTRYIPD EADFLLGMAT VNNCVSYRNP AEGTWYIQSL CQSLRERCPR GDDILTILTE VNYEVSNKDD KKNMGKQMPQ PTFTLRKKLV FPSD

交叉反应

人, 小鼠, 大鼠

产品特性

Polyclonal Antibodies

纯化方法

Affinity purification

免疫原

Recombinant fusion protein containing a sequence corresponding to amino acids 1-479 of human Caspase-8 (NP_001073593.1).

亚型

IgG

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anti-Caspase 8 (CASP8) (AA 410-449), (N-Term) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF 宿主: 小鼠 Monoclonal unconjugated

anti-Caspase 8 (CASP8) (AA 217-374) antibody
CASP8 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (pSer347) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

说明

HIGH QUALITY

限制

仅限研究用
状态

Liquid

缓冲液

PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Avoid freeze / thaw cycles.
Chen, Deng, Gan, Li, Huang, Lu, Wei, Su, Luo, Zou, Hong, Cao, Liu, Chi: "NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma." in: Molecular neurodegeneration, Vol. 15, Issue 1, pp. 26, (2020) (PubMed).

Song, Ma, Lu, Zhou, Zhao, Ai, Wei, Lin, Wang, Yan, Jiao: "The protective role of the MKP-5-JNK/P38 pathway in glucolipotoxicity-induced islet β-cell dysfunction and apoptosis." in: Experimental cell research, Vol. 382, Issue 1, pp. 111467, (2020) (PubMed).

Kong, Liu, Zhou, Hou, He, Li, Miao, Yang: "Downregulation of METTL14 increases apoptosis and autophagy induced by cisplatin in pancreatic cancer cells." in: The international journal of biochemistry & cell biology, Vol. 122, pp. 105731, (2020) (PubMed).

Zhao, Zhu, Bu, Zhou, Bai, Guo, Gao, Lu: "Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis." in: Redox biology, Vol. 29, pp. 101392, (2020) (PubMed).

Zhou, Li, Han, Feng, Liu, Chen, Liu, Zhao, Jin: "Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway." in: Investigational new drugs, Vol. 38, Issue 1, pp. 50-59, (2020) (PubMed).

Chen, Fang, Chen, Yang, Zhou, Mao, Xia, Jin, Li, You, Wang, Lei, He, Hu: "Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain-barrier disruption after ischemic stroke." in: Cell death & disease, Vol. 10, Issue 7, pp. 487, (2020) (PubMed).

Hu, Li, Yu, Liu, Wang, Qing, Wang, Wang, Zhu, Xu, Tan, Guo, Hui: "GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis." in: Free radical biology & medicine, Vol. 145, pp. 237-249, (2020) (PubMed).

Jin, Shi, Liu, Chen, Yang: "Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway." in: International journal of molecular sciences, Vol. 20, Issue 19, (2020) (PubMed).

Yu, Ye, Li, Zhan, Liu, Yan, Fang, Xie, Zhang, Chen, Ding, Chen: "Histone methyltransferase SETDB1 promotes colorectal cancer proliferation through the STAT1-CCND1/CDK6 axis." in: Carcinogenesis, Vol. 41, Issue 5, pp. 678-688, (2020) (PubMed).

Liu, Wei, Fang, Li, Li: "Giardia duodenalis induces extrinsic pathway of apoptosis in intestinal epithelial cells through activation of TNFR1 and K63 de-ubiquitination of RIP1 in vitro." in: Microbial pathogenesis, Vol. 149, pp. 104315, (2020) (PubMed).

Chen, Wei, Yang, Guo, Guo, Zhou: "Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 143, pp. 111517, (2020) (PubMed).

Yu, Zhu, Wang, Li, Hu, Qing, Wang, Wang, Wang, Xu, Guo, Hui: "LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK-eIF2α-ATF4-CHOP axis." in: Acta pharmacologica Sinica, (2020) (PubMed).

Chen, Gan, Li, Gu, Liu, Deng, Wang, Hong, Hu, Su, Chi: "NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye." in: The ocular surface, Vol. 18, Issue 4, pp. 783-794, (2020) (PubMed).

Cheng, Qin, Huang, Zhou, Xiong, Zhao, Zhang, Yu: "Cytokeratin 18 regulates the transcription and alternative splicing of apoptotic‑related genes and pathways in HeLa cells." in: Oncology reports, Vol. 42, Issue 1, pp. 301-312, (2019) (PubMed).

Zuo, Kong, Wang, Liu, Wang, Wan, Yan, Zhang, Tang, Zhang, Lyu, Li, Shan, Qian, Shen, Yu: "CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain." in: EMBO molecular medicine, Vol. 10, Issue 3, (2018) (PubMed).

Xu, Li, Jiang, Feng, Wu, Cai, Zhang, Huang, Sealy, Iqbal, Li: "Antiviral Immunotoxin Against Bovine herpesvirus-1: Targeted Inhibition of Viral Replication and Apoptosis of Infected Cell." in: Frontiers in microbiology, Vol. 9, pp. 653, (2018) (PubMed).

Cai, Lv, Kaldybayeva, Zhamilya, Wu, Wu: "15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 9, pp. 25, (2018) (PubMed).
抗原

Caspase 8 (CASP8)

别名

Casp8 (CASP8 产品)

别名

casp8-A antibody, xCaspase-8 antibody, casp8 antibody, CASP8 antibody, CASP-8 antibody, FLICE antibody, MACH antibody, Mch5 antibody, ALPS2B antibody, CAP4 antibody, Casp-8 antibody, MCH5 antibody, caspase-8 antibody, zgc:92075 antibody, caspase 8 L homeolog antibody, death related ced-3/Nedd2-like protein antibody, caspase 8 antibody, caspase-8 antibody, caspase-8-like antibody, caspase 8, apoptosis-related cysteine peptidase antibody, casp8.L antibody, LOC661095 antibody, CASP8 antibody, LOC5563818 antibody, casp8 antibody, LOC100222284 antibody, Casp8 antibody

背景

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.,ALPS2B,CAP4,Casp-8,FLICE,MACH,MCH5,Caspase 8,CASP8,Caspase-8,caspase-8,Cancer,Invasion and Metastasis,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Caspases,Mitochondrial Control of Apoptosis,Inhibition of Apoptosis,Ubiquitin,Death Receptor Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,Toll-like Receptor Signaling Pathway,Neuroscience,Neurodegenerative Diseases,Casp8

分子量

25-32 kDa/45- 61 kDa

基因ID

841

UniProt

Q14790

途径

Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades