我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

Lamin A/C 抗体 (AA 398-490)

Name: Lamin A/C 抗体 (AA 398-490)
SKU: ABIN968765
Availability: OutOfStock

LMNA 适用: 人, 小鼠, 大鼠, 犬, 小鸡 WB, IF 宿主: 小鼠 Monoclonal 14-LaminAC unconjugated

Western blot analysis of Lamin A/C on a HeLa lysate. (Lamin A/C 抗体 (AA 398-490))

1 image

(3 references)

产品编号 ABIN968765

发货至: 中国

Datasheet as PDF

抗原 See all Lamin A/C (LMNA) 抗体

Lamin A/C (LMNA)
抗原表位
10

8

7

7

5

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 398-490
适用
134

77

74

26

15

12

8

6

6

6

5

4

4

3

3

2

2

1

1

1

1

1

1
人, 小鼠, 大鼠, 犬, 小鸡
宿主
99

44

2

1
小鼠
Compatible Secondaries
克隆类型
101

45
单克隆
标记
109

9

8

6

2

2

2

2

1

1

1

1

1

1
This Lamin A/C antibody is un-conjugated
应用范围
116

54

52

46

31

29

28

16

12

7

3

2

1

1
Western Blotting (WB), Immunofluorescence (IF)

交叉反应

人, 小鸡, 犬, 小鼠, 大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human Lamin A/C aa. 398-490

克隆位点

14-LaminAC

亚型

IgG1

Top Product

Discover our top product LMNA Primary Antibody
anti-Lamin A/C (LMNA) (AA 403-572) antibody
LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (pSer392) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人 IHC, ELISA, IF, IP, FACS 宿主: 兔 Monoclonal 4H7 unconjugated Recombinant Antibody

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4E7 unconjugated

anti-Lamin A/C (LMNA) (AA 481-646) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (AA 455-469) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 133A2 unconjugated

anti-Lamin A/C (LMNA) (C-Term) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 猴, 马, 兔, Hamster, 小鸡, 绵羊, 豚鼠, Avian, Cat, 驴, 山羊 WB 宿主: 山羊 Polyclonal unconjugated

说明

Related Products: ABIN968535, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Shackleton, Lloyd, Jackson, Evans, Niermeijer, Singh, Schmidt, Brabant, Kumar, Durrington, Gregory, ORahilly, Trembath: "LMNA, encoding lamin A/C, is mutated in partial lipodystrophy." in: Nature genetics, Vol. 24, Issue 2, pp. 153-6, (2000) (PubMed).

Sullivan, Escalante-Alcalde, Bhatt, Anver, Bhat, Nagashima, Stewart, Burke: "Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy." in: The Journal of cell biology, Vol. 147, Issue 5, pp. 913-20, (1999) (PubMed).

McKeon, Kirschner, Caput: "Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins." in: Nature, Vol. 319, Issue 6053, pp. 463-8, (1986) (PubMed).
抗原

Lamin A/C (LMNA)

别名

Lamin A/C (LMNA 产品)

背景

The nuclear envelope (NE) is a specialized extension of the ER that contains numerous pore complexes interconnected with the nuclear lamina. The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus playing a major role in interphase nuclear organization. The major component of nuclear lamina are intermediate filament-like proteins called lamins. In mammalian somatic cells, there are three major lamins, A, B1, and C, and two minor lamins, B2 and A10. A-type lamins (A, A10, and C) are encoded by a single gene and are produced by alternative splicing, while B-type lamins (B1 and B2) are encoded by separate genes. B-type lamins are found in all nucleated somatic cells, while the expression of A-type lamins are developmentally regulated. Mice lacking lamin A show no overt abnormalities until postnatal development when perturbations in nuclear envelop structure correlate with the appearance of muscular dystrophy. In addition, lamin A is mutated in lipodystrophy, a disorder characterized by reduction in subcutaneous adipose tissue. Thus, lamin A and C may be important for nuclear envelope formation during postnatal cell differentiation. This antibody is routinely tested by western blot analysis.

分子量

65 & 74 kDa

途径

Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus