(2 references)-
- 抗原 See all XBP1 抗体
- XBP1 (X-Box Binding Protein 1 (XBP1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This XBP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 纯化方法
- Ascitic fluid
- 免疫原
- Purified recombinant fragment of human XBP1 expressed in E. Coli.
- 克隆位点
- 1C4
- 亚型
- IgG1
- Top Product
- Discover our top product XBP1 Primary Antibody
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anti-X-Box Binding Protein 1 (XBP1) (AA 300-376) antibody
XBP1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) antibodyXBP1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 51-150) antibodyXBP1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (Internal Region) antibodyVerified XBP1 适用: 人 WB, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-167) antibodyXBP1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 123-225) antibodyXBP1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3F5 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 62-91) antibodyXBP1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21824 unconjugated
anti-X-Box Binding Protein 1 (XBP1) (AA 1-261) antibodyXBP1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test. - 限制
- 仅限研究用
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- 状态
- Liquid
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
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: "Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14904-13, (2009) (PubMed).
: "Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 11, pp. 3834-41, (2009) (PubMed).
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: "Airway epithelial inflammation-induced endoplasmic reticulum Ca2+ store expansion is mediated by X-box binding protein-1." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14904-13, (2009) (PubMed).
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- 抗原
- XBP1 (X-Box Binding Protein 1 (XBP1))
- 别名
- XBP1 (XBP1 产品)
- 别名
- treb5 antibody, xXBP1 antibody, xbp2 antibody, XBP1P1 antibody, XBPP1 antibody, xbp1 antibody, TREB5 antibody, XBP-1 antibody, XBP2 antibody, D11Ertd39e antibody, TREB-5 antibody, HTF antibody, cb918 antibody, id:ibd1195 antibody, trebf antibody, wu:fb02h05 antibody, wu:fb63f10 antibody, xbp1a antibody, xbp1b antibody, X-box binding protein 1 antibody, X-box binding protein 1 L homeolog antibody, xbp1 antibody, XBP1 antibody, Xbp1 antibody, xbp1.L antibody
- 背景
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This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
Synonyms: XBP2, TREB5, XBP1 - 分子量
- 28kDa
- 基因ID
- 7494
- 途径
- ER-Nucleus Signaling, Unfolded Protein Response
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