MEK1 抗体
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北京 101111
Quick Overview for MEK1 抗体 (ABIN966563)
抗原
See all MEK1 (MAP2K1) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- MEK1 (Ab-221) antibody detects endogenous levels of total MEK1 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized non-phosphopeptide derived from human MEK1 around the phosphorylation site of serine 221 (A-N-SP-F-V).
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应用备注
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WB: 1:500~1:1000
IHC: 1:50~1:100. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100ug/100ul.
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia." in: Cancer research, Vol. 66, Issue 7, pp. 3401-8, (2006) (PubMed).
: "Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity." in: The Journal of biological chemistry, Vol. 279, Issue 50, pp. 52117-23, (2004) (PubMed).
: "Negative regulation of MAPKK by phosphorylation of a conserved serine residue equivalent to Ser212 of MEK1." in: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 8118-25, (2003) (PubMed).
: "MAD2-induced sensitization to vincristine is associated with mitotic arrest and Raf/Bcl-2 phosphorylation in nasopharyngeal carcinoma cells." in: Oncogene, Vol. 22, Issue 1, pp. 109-16, (2003) (PubMed).
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- MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
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别名
- MEK1
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途径
- MAPK Pathway, RTK signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
抗原
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