armd11 antibody, fb51d07 antibody, wu:fb24g06 antibody, wu:fb51d07 antibody, wu:fc55f03 antibody, zgc:136227 antibody, ARMD11 antibody, CysC antibody, CYSC antibody, cystatin C antibody, cystatin C L homeolog antibody, cystatin C (amyloid angiopathy and cerebral hemorrhage) antibody, cystatin 3 antibody, CST3 antibody, cst3.L antibody, cst3 antibody, cystatin 3 antibody, Cst3 antibody
背景
Cystatin C or cystatin 3, a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function. Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid, such as Alzheimer's disease. By human-rodent somatic cell hybridizations, Abrahamson et al. (1989) mapped the human CST3 to chromosome 20. Cystatin C was originally described as a constituent of normal cerebrospinal fluid (CSF) and of urine from patients with renal failure (Grubb and Lofberg, 1982). It is present in a number of neuroendocrine cells and its concentration in the CSF was reported to be 5.5 times that in plasma of healthy adults (Lofberg and Grubb, 1979, Lofberg et al., 1981, Lofberg et al., 1983). Grubb and Lofberg detected the protein in human pituitary gland, and suggested that it is part of the gastroenteropancreatic neuroendocrine system.