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CHEK2 抗体

This anti-CHEK2 antibody is a 兔 多克隆 antibody detecting CHEK2 in IHC. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN965891
发货至: 中国

Quick Overview for CHEK2 抗体 (ABIN965891)

抗原

See all CHEK2 抗体
CHEK2 (Checkpoint Kinase 2 (CHEK2))

适用

  • 237
  • 86
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  • 1
人, 小鼠, 大鼠

宿主

  • 217
  • 22
  • 1

克隆类型

  • 206
  • 34
多克隆

标记

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  • 3
  • 3
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  • 3
  • 3
  • 2
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  • 1
This CHEK2 antibody is un-conjugated

应用范围

  • 202
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  • 5
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Immunohistochemistry (IHC)
  • 特异性

    Chk2 (Ab-68) antibody detects endogenous levels of total Chk2 protein.

    纯化方法

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

    免疫原

    The antiserum was produced against synthesized non-phosphopeptide derived from human Chk2 around the phosphorylation site of threonine 68.
  • 应用备注

    WB: 1:500~1:1000
    IHC: 1:50~1:100.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    100ug/100ul.

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • Bhoumik, Takahashi, Breitweiser, Shiloh, Jones, Ronai: "ATM-dependent phosphorylation of ATF2 is required for the DNA damage response." in: Molecular cell, Vol. 18, Issue 5, pp. 577-87, (2005) (PubMed).

    Gorgoulis, Vassiliou, Karakaidos, Zacharatos, Kotsinas, Liloglou, Venere, Ditullio, Kastrinakis, Levy, Kletsas, Yoneta, Herlyn, Kittas, Halazonetis: "Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions." in: Nature, Vol. 434, Issue 7035, pp. 907-13, (2005) (PubMed).

    Jin, Kurosu, Yamaguchi, Arai, Miura: "Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis." in: Oncogene, Vol. 24, Issue 12, pp. 1973-81, (2005) (PubMed).

    Li, Stern: "Regulation of CHK2 by DNA-dependent protein kinase." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 12041-50, (2005) (PubMed).

  • 抗原

    CHEK2 (Checkpoint Kinase 2 (CHEK2))

    别名

    CHK2

    途径

    p53 Pathway, Apoptosis, Cell Division Cycle
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