OCT6 antibody, OTF6 antibody, SCIP antibody, Oct-6 antibody, Oct6 antibody, Otf-6 antibody, Otf6 antibody, Scip antibody, Test1 antibody, Tst-1 antibody, Tst1 antibody, pou50 antibody, wu:fc09d06 antibody, zp-50 antibody, zp50 antibody, zp50pou antibody, Testes-1 antibody, Xlnrl-34 antibody, nrl-22 antibody, nrl-34 antibody, nrl34-A antibody, oct-6 antibody, oct6 antibody, pou3f1 antibody, scip antibody, pou1-A antibody, POU class 3 homeobox 1 antibody, POU domain, class 3, transcription factor 1 antibody, POU class 3 homeobox 1 L homeolog antibody, POU class 3 homeobox 1 S homeolog antibody, POU3F1 antibody, Pou3f1 antibody, pou3f1 antibody, pou3f1.L antibody, pou3f1.S antibody
背景
POU homeodomain proteins are transcriptional regulators that function in various developmental processes (e.g. cell division, differentiation, specification and survival of specific cell types) and participate in the determination of cell fate. The 45 kDa POU transcription factor Oct-6 (also designated SCIP and Tst-1) is expressed by late embryonic Schwann cells of the peripheral nervous system and is also expressed by nonmyelinating Schwann cells in adults. Oct-6 is strongly upregulated in promyelin cells because it is required for the timely differentiation of promyelin cells into myelinating cells. Oct-6 functions during myelination and is required for the proper downregulation of its own gene when myelination proceeds. c-Myc can act synergistically with the POU domain of Oct-6 to produce myelin disease pathogenesis in the mammalian central nervous system.Synonyms: OTF6, Oct-6, Octamer-binding protein 6, Octamer-binding transcription factor 6, POU domain class 3 transcription factor 1, POU domain transcription factor SCIP, SCIP