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PD-1 抗体 (FITC)

PDCD1 适用: 小鼠 FACS 宿主: 仓鼠 Monoclonal J43 FITC
产品编号 ABIN951269
发货至: 中国
  • 抗原 See all PD-1 (PDCD1) 抗体
    PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
    适用
    • 132
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    小鼠
    宿主
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    仓鼠
    克隆类型
    • 126
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    单克隆
    标记
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    This PD-1 antibody is conjugated to FITC
    应用范围
    • 120
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    Flow Cytometry (FACS)
    特异性
    This Monoclonal Antibody reacts with Mouse PD-1 (Programmed Death-1).
    纯化方法
    Protein G Chromatography
    免疫原
    PD-1 cDNA transfectant. Donor: mouse ascites fluid. Fusion Partner: Mouse myeloma P3U1.
    克隆位点
    J43
    亚型
    IgG
    Top Product
    Discover our top product PDCD1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.1 mg/mL
    缓冲液
    PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
    别名
    CD279 / PD1 (PDCD1 产品)
    别名
    CD279 antibody, PD-1 antibody, PD1 antibody, SLEB2 antibody, hPD-1 antibody, hPD-l antibody, Ly101 antibody, Pdc1 antibody, programmed cell death 1 antibody, PDCD1 antibody, Pdcd1 antibody
    背景
    CD279 is 50-55kD membrane protein which is a member of the CD28 family, and functions mainly as a negative regulator of T-cell activation. CD279 has two specific ligands, CD274 (PD-L1) and CD273 (PD-L2), and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance. CD279 is inducibly expressed by T-cells, B-cells, NK-T-cells and monocytes upon activation. Loss of CD279 function has been associated with a number of autoimmune diseases, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis. Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion.Synonyms: PDCD1, Programmed cell death protein 1, Protein PD-1, hPD-1
    基因ID
    18566
    NCBI登录号
    NP_032824
    UniProt
    Q02242
    途径
    Cancer Immune Checkpoints
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