Recognizes CACNB2 (565-579). This antibody is expected to recognize all reported isoforms (NP_000715.2, NP_963890.2, NP_963884.2, NP_963891.1, NP_963887.2, NP_963865.2, NP_963864.1, NP_963866.2, NP_001161417.1).
交叉反应 (详细)
Species reactivity (expected):Rat, Dog, Cow. Species reactivity (tested):Human, Mouse.
纯化方法
Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
免疫原
Peptide with sequence from the C Terminus of the protein sequence according to NP_000715.2, NP_963890.2, NP_963884.2, NP_963891.1, NP_963887.2, NP_963865.2, NP_963864.1, NP_963866.2, NP_001161417.1. Genename: CACNB2
Heterologous expression studies have shown that the activity of voltage-gated Ca2+ channels is regulated by their beta subunits in a beta subunit isoform-specific manner. Our data show that all four beta subunit isoforms associate with L-type Ca2+ channels in mammalian brain. This beta subunit heterogeneity may play an important role for the fine tuning of L-type channel function and modulation in neurons.Synonyms: CAB2, CACNLB2, Calcium channel voltage-dependent subunit beta 2, Lambert-Eaton myasthenic syndrome antigen B, MYSB, Voltage-dependent L-type calcium channel subunit beta-2