SETD7 抗体 (AA 271-366) (Alexa Fluor 488)
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- 抗原 See all SETD7 抗体
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
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抗原表位
- AA 271-366
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SETD7 antibody is conjugated to Alexa Fluor 488
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人
- 预测反应
- Mouse,Rat,Dog,Cow,Pig,Horse
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7
- 亚型
- IgG
- Top Product
- Discover our top product SETD7 Primary Antibody
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- 应用备注
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FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- SETD7 (SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
- 别名
- H3-K4-HMTase SETD7 (SETD7 产品)
- 别名
- KMT7 antibody, SET7 antibody, SET7/9 antibody, SET9 antibody, set7 antibody, zgc:101860 antibody, zgc:92330 antibody, 1600028F23Rik antibody, H3K4MT antibody, Set7 antibody, Set7/9 antibody, mKIAA1717 antibody, SET domain containing lysine methyltransferase 7 antibody, SET domain containing (lysine methyltransferase) 7 antibody, SETD7 antibody, setd7 antibody, Setd7 antibody
- 背景
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Synonyms: FLJ21193, H3 K4 HMTase, H3-K4-HMTase SETD7, H4 lysine 4 specic, Histone H3 K4 methyltransferase, Histone H3 lysine 4 specic methyltransferase, Histone H3-K4 methyltransferase SETD7, Histone H4 K4 methyltransferase, Histone lysine N methyltransferase, Histone lysine N methyltransferase H3 lysine 4 specic SET7, Histone-lysine N-methyltransferase SETD7, KIAA1717, KMT7, Lysine methyltransferase, Lysine N-methyltransferase 7, OTTHUMP00000164543, OTTHUMP00000220049, SET 7, SET 7/9, SET 9, SET D7, SET domain containing lysine methyltransferase 7, SET domain containing protein 7, SET domain containing protein 8, SET domain-containing protein 7, SET7, SET7/9, SET9, Setd7, SETD7_HUMAN.
Background: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
- 基因ID
- 80854
- UniProt
- Q8WTS6
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