The antibody detects endogenous level of total E2F-2 protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 425-429 (L-F-D-S-Y) derived from Human E2F-2. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner.