The antibody detects endogenous levels of total TFE3 protein.
纯化方法
Affinity purified
免疫原
Peptide sequence around AA 303-307 (L-D-V-Y-S) derived from Human TFE3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.