Activin A Receptor Type IB/ALK-4 抗体 (AA 51-150)
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- 抗原 See all Activin A Receptor Type IB/ALK-4 (ACVR1B) 抗体
- Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
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抗原表位
- AA 51-150
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Activin A Receptor Type IB/ALK-4 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 大鼠
- 预测反应
- Human,Mouse,Dog,Cow,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human ACVR1B
- 亚型
- IgG
- Top Product
- Discover our top product ACVR1B Primary Antibody
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anti-Activin A Receptor, Type IB (ACVR1B) antibody
ACVR1B 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 24-126) antibodyACVR1B 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1C1 unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 39-68), (N-Term) antibodyACVR1B 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal RB3740 unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 24-126) antibodyACVR1B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 1-505) antibodyACVR1B 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 24-126) antibodyACVR1B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D4 unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 24-126) antibodyACVR1B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6D3 unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (Internal Region) antibodyACVR1B 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (AA 73-122) antibodyACVR1B 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IB (ACVR1B) (C-Term) antibodyACVR1B 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))
- 别名
- Acvr1b (ACVR1B 产品)
- 别名
- ACVR1B antibody, alk4 antibody, skr2 antibody, alk-4 antibody, xalk4 antibody, actrib antibody, acvrlk4 antibody, DKFZp469A1614 antibody, 6820432J04 antibody, ActR-IB antibody, ActRIB antibody, Acvrlk4 antibody, Alk4 antibody, SKR2 antibody, ACTRIB antibody, ACVRLK4 antibody, ALK4 antibody, Skr2 antibody, axis antibody, taram-a antibody, tarama antibody, wu:fb75f01 antibody, activin A receptor type 1B antibody, Activin receptor type-1B antibody, activin A receptor, type IB antibody, activin A receptor, type 1B antibody, activin A receptor type 1Ba antibody, ACVR1B antibody, acvr1b antibody, acv1b antibody, Acvr1b antibody, acvr1ba antibody
- 背景
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Synonyms: ALK4, SKR2, ACTRIB, ACVRLK4, Activin receptor type-1B, Activin receptor type IB, ACTR-IB, Activin receptor-like kinase 4, ALK-4, Serine/threonine-protein kinase receptor R2, ACVR1B
Background: Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
- 基因ID
- 91
- UniProt
- P36896
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