RAD51 抗体 (AA 1-258) (HRP)
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北京 101111
Quick Overview for RAD51 抗体 (AA 1-258) (HRP) (ABIN7985968)
抗原
See all RAD51 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-258
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原理
- Anti-Rad51 Antibody HRP Conjugated
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特异性
- No cross reactivity with other proteins.
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交叉反应 (详细)
- No cross-reactivity with other proteins
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预测反应
- Human Rad51 shares 98% amino acid (aa) sequence identity with mouse Rad51.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Rad51 recombinant protein (Position: M1-E258). Human Rad51 shares 98% amino acid (aa) sequence identity with mouse Rad51.
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亚型
- IgG
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应用备注
- Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.
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储存条件
- -20 °C
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储存方法
- At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.
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有效期
- 12 months
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- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
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别名
- RAD51
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背景
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Background: DNA repair protein RAD51 homolog 1, also known as RAD51A, is a human gene. The Rad51 gene, HsRAD51, is a homolog of RecA of Escherichia coli and functions in recombination and DNA repair. BRCA1 and BRCA2 proteins form a complex with Rad51, and these genes are thought to participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. RAD51 is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis.
Gene Full Name: RAD51 recombinase
Sequence Similarities: Belongs to the RecA family. RAD51 subfamily.
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基因ID
- 5888
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UniProt
- Q06609
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途径
- DNA Damage Repair
抗原
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