Recombinant GRB2 抗体
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北京 101111
Quick Overview for Recombinant GRB2 抗体 (ABIN7880931)
抗原
See all GRB2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- GRB2 Antibody / Growth factor receptor-bound protein 2
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human GRB2 was used as the immunogen for the GRB2 antibody.
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibody
GRB2 适用: 人, 小鼠, 大鼠, 犬, 小鸡 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (C-Term) antibodyVerified GRB2 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibodyGRB2 适用: 人 WB, IHC, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (C-Term) antibodyKO Validated GRB2 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibodyKD Validated GRB2 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6275 unconjugated Recombinant Antibody
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 89-118) antibodyGRB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibodyGRB2 适用: 人, 小鼠, 大鼠, Cow, Hamster WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 156-217) antibodyGRB2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 89-118) antibodyGRB2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB15648 unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 187-216) antibodyGRB2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB11305-11306 unconjugated
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应用备注
- Optimal dilution of the GRB2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store the GRB2 antibody at -20oC.
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- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
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别名
- GRB2
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背景
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GRB2 antibody detects growth factor receptor-bound protein 2, an adaptor protein central to receptor tyrosine kinase (RTK) signaling. GRB2 consists of one SH2 domain flanked by two SH3 domains, enabling it to couple activated receptors to downstream Ras-MAPK pathways. By binding to phosphorylated tyrosine residues on activated receptors or adaptor proteins such as Shc, GRB2 recruits SOS (Son of Sevenless), which activates Ras and drives proliferation and differentiation signals.
Research using GRB2 antibody underscores its importance in cell signaling. GRB2 is ubiquitously expressed and links a wide variety of RTKs, including EGFR, PDGFR, and FGFR, to MAPK cascades. It also mediates signaling downstream of cytokine receptors, integrins, and immune receptors. GRB2 serves as a hub for integrating growth factor, adhesion, and immune signaling into coherent cellular responses.
Dysregulation of GRB2 activity has been implicated in cancer. Overexpression enhances mitogenic signaling, contributing to tumor initiation and progression. In leukemias, GRB2 forms oncogenic fusion proteins, such as BCR-GRB2, which sustain aberrant Ras signaling. GRB2 is also involved in resistance mechanisms to targeted therapies, where cancer cells bypass inhibited kinases by upregulating adaptor-mediated pathways.
Beyond oncology, GRB2 contributes to immune function, where it regulates T-cell receptor signaling and immune synapse assembly. Genetic studies have linked GRB2 activity to autoimmune conditions and altered inflammatory responses. In developmental biology, GRB2 is essential for embryogenesis, with knockout models demonstrating lethality due to impaired RTK signaling.
Antibodies against GRB2 are validated for western blot, immunoprecipitation, and immunofluorescence. These reagents enable detection of GRB2 expression, assessment of protein-protein interactions, and mapping of RTK signaling dynamics. Clone-based GRB2 antibodies provide specificity across experimental systems, ensuring reproducibility.
NSJ Bioreagents provides this GRB2 antibody for cancer biology, immunology, and cell signaling research. -
UniProt
- P62993
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途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
抗原
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