TRAF1 抗体 (AA 73-219)
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Quick Overview for TRAF1 抗体 (AA 73-219) (ABIN7876671)
抗原
See all TRAF1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 73-219
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原理
- TRAF1 Antibody (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A portion of amino acids 73-219 from the human protein was used as the immunogen for the TRAF1 antibody.
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亚型
- IgG1, kappa
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anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 301-416) antibody
TRAF1 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (C-Term) antibodyVerified TRAF1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 73-219) antibodyTRAF1 适用: 人 IHC 宿主: 小鼠 Monoclonal TRAF1-2770 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 131-381) antibodyTRAF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2G9-G10 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (C-Term) antibodyTRAF1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 73-219) antibodyTRAF1 适用: 人 IHC 宿主: 小鼠 Monoclonal TRAF1-3298 unconjugated
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应用备注
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Optimal dilution of the TRAF1 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the TRAF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))
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别名
- TRAF1
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背景
- This mAb recognizes a protein of 52 kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30 % of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84 %) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7 %). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
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UniProt
- Q13077
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途径
- NF-kappaB Signaling, Apoptosis, Cell-Cell Junction Organization, Asymmetric Protein Localization
抗原
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